依那普利降低腹主动脉结扎大鼠房颤诱发率  

Study on the Effect of Enalapril on Inducible Atrial Fibrillation in Abdominal Aorta Banded Rats

作　　者：刘英明[1] 朱智明[2] 卢才义[1] 石湘芸[2] 徐斌[1] 王士雯[1] 

机构地区：[1]北京解放军总医院老年心血管病研究所,100853 [2]北京海军总医院海军心血管内科专科中心

出　　处：《天津医药》2004年第12期760-762,共3页Tianjin Medical Journal

摘　　要：目的 :研究依那普利对腹主动脉结扎大鼠房颤诱发率的影响 ,探讨高血压相关性房颤的防治措施。方法 :雄性SD大鼠随机分为对照组 (C组 )、腹主动脉结扎组 (AB组 )和腹主动脉结扎 +依那普利组 (AB E组 ) ,每组 12只。在肾上部位进行腹主动脉结扎。动物麻醉后通过多导生理记录仪记录Ⅰ导体表心电图和颈动脉压力曲线。在体外灌流的条件下 ,采用心房短阵刺激评价房间传导时间 (IACT)和心房对猝发刺激的反应。结果 :与C组比较 ,AB组P波持续时间和IACT延长 ,诱发出 4例房颤 ,血浆血管紧张素Ⅱ浓度和心房纤维化程度增加 ;与AB组比较 ,AB E组P波持续时间和IACT缩短 ,血浆血管紧张素Ⅱ浓度和心房纤维化程度降低 ;C组和AB E组均未能诱发出房颤。结论 :依那普利通过降低血管紧张素Ⅱ水平 ,减轻心房纤维化 ,降低腹主动脉结扎大鼠房颤诱发率。Objective:To study the effect of enalapril on the inducible atrial fibrillation in abdominal aorta banded rats and explore the prevention and therapeutic methods for hypertension related atrial fibrillation.Methods:Male Sprague-Dawley rats were randomly divided into control group (group C,n=12),abdominal aorta banded group (group AB,n=12),and abdominal aorta banded plus enalapril group (group AB-E,n=12).A suprarenal aortic band was placed in AB group and AB-E group. Lead I body surface electrocardiograph and carotid pressure curve were recoreded through multiple leads physiological recorder after animal anesthetized.Interatrial conduction time (IACT) and atrial response to burst atrial pacing were evaluated in Langendorf-perfused setting.Results:Compared with group C, P wave duration and IACT were longer in AB group. Atrial fibrillation was induced in 4 rats in AB group. The degree of angiotensin Ⅱ and atrial fibrosis were increased. Compared with AB group, P wave duration and IACT were shorter in AB-E group, the degree of angiotensin Ⅱ and atrial fibrosis were decreased. No such arrhythmia could be induced in group C and AB-E group.Conclusion:Enalapril can decrease inducible atrial fibrillation in abdominal aorta banded rats through lowering concentration of angiotensin Ⅱ and decreasing atrial fibrosis.

关 键 词：依那普利 腹主动脉结扎 大鼠 诱发率 高血压 心房颤动 

分 类 号：R541.75[医药卫生—心血管疾病] R972[医药卫生—内科学]