血前降钙素在小儿重症感染诊断中的作用  

Application of measurement of serum procalcitonin in the diagnosis of severe infection in children

作　　者：张瑾[1] 张灵恩[1] 黄剑峰[1] 周渊峰[1] 贡海蓉[1] 

机构地区：[1]复旦大学附属儿科医院,上海200032

出　　处：《小儿急救医学》2004年第6期386-388,共3页Pediatric Emergency Medicine

摘　　要：目的　评价血清前降钙素在重症感染诊断中的作用。方法　应用免疫荧光法对 30例重症感染患儿于入院时和入院后 4 8h进行血清前降钙素水平测定 ,并比较血清CRP、白细胞计数对感染疾病的实验室诊断价值。结果　 17例细菌感染患儿血清前降钙素水平明显升高 ,13例病毒感染患儿血前降钙素水平正常或仅有轻度升高。血清CRP在两组间有数据重叠。经有效抗生素治疗后 ,血清前降钙素水平的下降幅度明显大于血清的下降幅度 (P分别为 0 0 2 8和 0 196 )。结论　血前降钙素是鉴定细菌感染和病毒感染的重要指标 。Objective To evaluate the value of serum procalcitonin(PCT) in children with severe infection.Methods The serum PCT levels were measured with an immunoluminometric assay and compared with the serum C-reactive protein(CRP) and the counts of white blood cells(WBC)in 30 children with severe infection at admission and repeated 48h later.Results The mean value of the serum PCT in 17 children with severe bacterial infections were higher than that in 13 children with viral infections,while the date of the serum CRP showed a zone of overlapping values between two groups.The level of the serum PCT decreased rapidly during effective antibiotic therapy.Conclusion The measurement of the serum PCT is valuabole in the differential diagnosis of bacterial or viral infection and PCT levels have a better prognostic value than CRP of neutrophil count.

关 键 词：前降钙素 严重感染 C反应蛋白 

分 类 号：R725.1[医药卫生—儿科]