可溶性肿瘤坏死因子受体I与颈动脉粥样硬化及其危险因素的相关性研究  

Relationship between soluble tumor necrosis factor receptor I and carotid atherosclerosis and its risk factors

作　　者：李静[1] 黎莉[1] 安丰双[1] 张运[1] 李晶晶[1] 

机构地区：[1]山东大学齐鲁医院心内科,山东济南250012

出　　处：《中国心血管杂志》2004年第6期418-420,共3页Chinese Journal of Cardiovascular Medicine

摘　　要：目的　研究血清可溶性肿瘤坏死因子受体 I(s TNFRI)水平与颈动脉粥样硬化的关系。方法　采用超声诊断仪将 82例中老年患者分为斑块形成组与无斑块组 ,分析两组 s TNFRI水平变化及与多种颈动脉粥样硬化危险因素的相关性。结果　斑块形成组冠心病、高血压、糖尿病及脑梗死的发生率较无斑块组显著增高 ,斑块形成组s TNFRI水平显著高于无斑块组 ,s TNFRI升高组比正常组颈动脉内膜 -中层厚度 (IMT)显著增加。多元逐步回归分析示 s TNFRI水平与年龄相关。结论　 s TNFRI水平与颈动脉 IMT相关。降低血清 s TNFRI浓度 ,抑制炎症反应不仅可能阻止颈动脉粥样硬化的进展 ,而且对于预防心。Objective To study the relationship between serum soluble tumor necrosis factor receptor I(sTNFRI) and carotid atherosclerosis and its risk factors. Methods 82 middle-old patients were divided into the group with plaques and the group without plaques by carotid ultrasound, then the levels of sTNFRI and the relationship between carotid atherosclerosis and its risk factors were analyzed. Results The rates of coronary heart disease, hypertension, diabetes mellitus and cerebral infarction were significantly higher in the group with plaques than the group without plaques. The levels of sTNFRI were significantly higher in the group with plaques than the group without plaques. IMT were significantly higher in the high sTNFRI group than normal sTNFRI group. Multiple stepwise regression showed sTNFRI level was independently correlated with age.Conclusion sTNFRI level was independently correlated with carotid IMT. Reducing sTNFRI and inflammation could not only prevent the progress of carotid atherosclerosis but also prevent cardiovascular and cerebrovascular events.

关 键 词：可溶性肿瘤坏死因子受体Ⅰ 颈动脉 动脉粥样硬化 

分 类 号：R543[医药卫生—心血管疾病]