紫外光照射下富勒醇对细胞的防护作用  

The effect of fullerols under UV on cell

作　　者：李宇国[1] 倪瑾[2] 韩玲[2] 赵群芬[1] 高福[2] 李晴暖[1] 徐晶莹[1] 李文新[1] 

机构地区：[1]中国科学院上海应用物理研究所纳米生物医药研究室,上海201800 [2]第二军医大学放射医学教研室,上海200438

出　　处：《辐射研究与辐射工艺学报》2004年第6期356-360,共5页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金(30200069和19975066)资助

摘　　要：为了解紫外辐射下富勒烯衍生物富勒醇对细胞的生物效应,利用四唑盐比色实验(MTT)法研究了富勒醇对紫外辐照细胞的存活率影响,紫外辐照细胞时富勒醇对细胞超氧化物岐化酶(SOD)和氧化产物丙二醛(MDA)的影响,同时比较了C60?PVP对紫外辐照细胞的辐射生物效应。结果表明,富勒醇能够有效的防护紫外辐射对细胞造成的损伤,其机理可能是富勒醇能够吸收紫外辐照产生的自由基,使细胞膜不被紫外辐照损伤。The UV radioprotcetive effect of fullerols, which was compared with the effect of C60-PVP, was studied using cultured L02 cells. The cell survivals were determined by MTT method, SOD and MDA also were studied with chemistric colorimetry. The results showed that fullerols can effectively protect cells from damage induced by UV irradiation. The mechanism could be assosiated with the ability of fullerols to behave as an antioxidant compound, then fullerols protected cell membrane from damage by UV radiation.

关 键 词：富勒烯 紫外辐照 辐射保护 

分 类 号：O644[理学—物理化学]