Synthesis and Crystal Structure of 4-(4-Chlorophenyl)-6-methyl-5-methoxy-caronyl-3,4-dihydropyrimidin-2(H)-one  

作　　者：华国平  屠树江  房芳  屠蔓苏  史达清  王香善  纪顺俊  张勇  

机构地区：[1]Xuzhou Institute of Architectural Technology, Xuzhou, Jiangsu 221008, China [2]Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou, Jiangsu 221009, China [3]College of Chemistry and Chemical Engineering, Key Lab of Organic Synthesis of Jiangsu Province, Suzhou University, Jiangsu 215006, China

出　　处：《Chinese Journal of Structural Chemistry》2004年第11期1295-1299,共5页结构化学（英文）

基　　金：This work was supported by the NNSFC (No. 20372057); Natural Science Foundation of Jiangsu Province (No. BK2001142); the Open Foundation of Key Laboratory of Organic Synthesis of Jiangsu Province; College of Chemistry and Chemical Engineering; Su

摘　　要：The title compound 4-(4-chlorophenyl)-6-methyl-5-methoxy-caronyl-3,4-dihydro- pyrimidin-2(H)-one has been synthesized by the reaction of 4-chlorobenzaldehyde, methyl acetoa- cetate and urea using H3BO3 as a catalyst under microwave irradiation. Its structure was charac- terized by X-ray single-crystal diffraction techniques with the following data: triclinic, space group P1, a = 5.4513(4), b = 7.619(1), c = 16.118(4) ?, α = 80.42(1), β = 83.43(1), γ = 79.29(1)°, V = 646.19(19) ?3, Mr = 280.70, μ(MoKα) = 0.301 mm-1, Z = 2 and Dc = 1.443 g/cm3. In the molecule the pyrimidine ring is of boat conformation.The title compound 4-(4-chlorophenyl)-6-methyl-5-methoxy-caronyl-3,4-dihydro- pyrimidin-2(H)-one has been synthesized by the reaction of 4-chlorobenzaldehyde, methyl acetoa- cetate and urea using H3BO3 as a catalyst under microwave irradiation. Its structure was charac- terized by X-ray single-crystal diffraction techniques with the following data: triclinic, space group P1, a = 5.4513(4), b = 7.619(1), c = 16.118(4) ?, α = 80.42(1), β = 83.43(1), γ = 79.29(1)°, V = 646.19(19) ?3, Mr = 280.70, μ(MoKα) = 0.301 mm-1, Z = 2 and Dc = 1.443 g/cm3. In the molecule the pyrimidine ring is of boat conformation.

关 键 词：microwave irradiation 3 4-dihydropyrimidinone H3BO3 crystal structure 

分 类 号：O626.41[理学—有机化学]