硝苯地平在聚吡咯膜修饰电极上的电化学行为及电位溶出分析  

Determination of Nifedipine in Polymerized Pyrrole Film by Linear Scan Stripping Voltammetry

作　　者：程发良[1] 吴剑[1] 张敏 汪洪[1] 

机构地区：[1]东莞理工学院生物传感器研究中心,广东东莞523106

出　　处：《分析测试学报》2004年第6期14-17,共4页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目 (20375008) ;广东省自然科学基金资助项目 (32167) ;广东省科技攻关项目 (C31902)

摘　　要：提出了在吡咯的聚合过程将硝苯地平掺杂富集进聚吡咯膜中 ,然后在合适的溶液中通过线性扫描将之溶出的分析方法。与空白聚吡咯修饰电极 (PPy-GCE)比较 ,在0.088mol/LH2O2-0.1mol/LH2SO4 底液中 ,以100mV/s的速率进行线性扫描时 ,硝苯地平有一灵敏的线性扫描溶出峰 ,峰电位在 -0.628V(vs.SCE)。峰电流与硝苯地平的浓度在1×10 -8～1×10 -4mol/L范围内有良好的线性关系 ,利用这一峰对硝苯地平片剂的含量进行了测试 。A new stripping voltammetric method for the determination of nifedipine(Nif)was developed.It was based on the collection of Nif on the polymerized pyrrole(PPy)film,and the stripping of the collected Nif with linear scan stripping voltammetry in an appropriate solution.In contrast to the voltammogram of the blank PPy-glass carbon electrode(GCE)in a supporting electrolyte of0.088mol/L H 2 O 2 -0.1mol/L H 2 SO 4 at a scan rate of100mV/s,a sensitive Nif peak appeared at the potential of-0.628V.The peak current was directly proportional to the concentration of Nifs over a range of1×10 -8 ～1×10 -4 mol/L.The develˉoped method has been applied to the determination of Nif in tablet with satisfactory results.

关 键 词：硝苯地平 聚吡咯膜修饰电极 电化学行为 电位溶出分析 片剂 含量测定 钙离子拮抗剂 血管扩张剂 

分 类 号：R972.4[医药卫生—药品] R927.2[医药卫生—药学]