2,4,5-三氟苯甲酸的合成  

Synthesis of 2,4,5-Trifluorobenzoic Acid

作　　者：张明泉[1] 杨郭明[1] 商志才[1] 俞庆森[1] 

机构地区：[1]浙江大学化学系,浙江杭州310027

出　　处：《中国医药工业杂志》2004年第12期714-715,共2页Chinese Journal of Pharmaceuticals

摘　　要：用2,4-二氯-5-氟苯甲酸和氯化亚砜反应得到的酰氯,经氨水酰胺化后脱水生成2,4-二氯-5-氟苄腈,再经氟代、水解制得2,4,5-三氟苯甲酸,总收率46%。Trifluorobenzoic acid was synthesized from2,4-dichloro-5-fluorobenzoic acid by chlorination, amidation and dehydration to give2,4-dichloro-5-fluorobenzylcyanide, which subjected to fluorination and hydrolysis with an overall yield of 46%.

关 键 词：2 4 5-三氟苯甲酸 克林沙星 中间体 合成 

分 类 号：O625.53[理学—有机化学]