氟桂嗪与尼莫地平防治偏头痛的多中心随机对照  

Multi-central randomized controlled study on flunarizine and nimodipine for prevention and treatment of migraine

作　　者：李义召[1] 曹秀玲[2] 朱士文[1] 宋成忠[1] 谢遵伟[1] 夏作理[3] 李明欣[4] 孙刚顺 任文博 范道长 王爱华[8] 张红梅[9] 张华芳[10] 卢林[11] 

机构地区：[1]济南长城医院神经内科,山东省济南市250100 [2]山东大学齐鲁医院科研处,山东省济南市250012 [3]泰山医学院脑血管病研究所,山东省泰安市271000 [4]山东大学齐鲁医院神经内科,山东省济南市250012 [5]梁山县人民医院神经内科,山东省梁山县272000 [6]山东省警官医院神经内科,山东省济南市250001 [7]东明县中医院神经内科,山东省东明县274000 [8]山东省千佛山医院神经内科,山东省济南市250000 [9]济南市立四院神经内科,山东省济南市250000 [10]潍坊市人民医院神经内科,山东省潍坊市261041 [11]山东省立医院神经内科,山东省济南市250021

出　　处：《中国临床康复》2004年第35期7906-7908,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:观察氟桂嗪与尼莫地平防治偏头痛的疗效,并探讨其作用机制。方法:2001/2004,济南长城医院神经内科,山东大学齐鲁医院神经内科,泰山医学院脑血管病研究所,梁山县人民医院神经内科,山东省警官医院神经内科,东明县中医院神经内科,山东省千佛山医院神经内科,济南市立四院神经内科,潍坊市人民医院神经内科,山东省立医院神经内科。选择 220例偏头痛患者,随机分为两组,氟桂嗪治疗组与尼莫地平治疗组,每组各 110例。采用视觉线性模拟量表 visuallinear (analogue scale,VAS)、文字分级量表 verbalrating scale,VRS)及疗程中 (非疼痛时间判断疗效。采用放免法测定血浆 β-内啡肽、神经降压素、内皮素、环磷酸腺苷与环磷酸鸟苷水平变化。结果:纳入统计分析 200例,氟桂嗪治疗组与尼莫地平治疗组各 100例。氟桂嗪组治疗后 VAS(3.6±1.7)cm ,较治疗前(7.3±2.6)cm 显著降低(P<0.01),VRS( 2.0±0.4)分,较治疗前 3.9±0.7)分显著降低(P (<0.01),非疼痛时间(15±4)d,较治疗前(7±2)d 显著增多(P <0.01);尼莫地平组治疗后 VAS(5.2±1.9)cm,较治疗前 7.2±2.2)cm 显著 (降低 P <0.05),VRS(2.9±0.AIM:To observe the effects and mechanisms of flunarizine and nimodipine for prevention of migraine. METHODS:From 2001 to 2004,totally 200 cases of migraine were selected Department of Neurology,Jinan Changcheng Hospital,Department of Neurology,Qilu Hospital of Shandong University,Institute of Cerebralvascular Disease,Taishan Medical College,Department of Neurology,Liangshan People's Hospital,Department of Neurology,Police Hospital of Shandong Province,Department of Neurology,Dongming Hospital of Traditional Chinese Medicine,Department of Neurology,Qianfu Mountain Hospital of Shandong Province,Department of Neurology,Fourth Municipal Hospital of Jinan, Department of Neurology,Weifang People's Hospital, Department of Neurology,Shandong Province People's Hospital, and the patients were randomized into two groups: flunarizine group(n=100) and nimodipine group(n=100).The therapeutic effects were observed with visual linear analogue scale(VAS),verbal rating scale(VRS) and non-ache days during treatment. The levels of β-endorphin(β-EP),neurotensin(NT),endothelins(ET) and cyclic adenosine monophosphate(cAMP) and cyclic guanosine monophosphate(cGMP) in plasma were measured by radioimmunoassay before and after treatment with flunarizine and nimodipine. RESULTS: In the flunarizine group,VAS and VRS after treatment[(3.6±1.7)cm and(2.0±0.4)scores]were lower than those before treatment[(7.3±2.6)cm and(3.9±0.7)scores](P< 0.01),and non-ache days during treatment[(15±4)days]were more than thosebefore treatment[(7±2)days](P< 0.01).In the nimodipine group,VAS and VRS after treatment [(5.2±1.9)cm and(2.9±0.5)scores respectively[were lower than those before treatment[(7.2±2.2)cm and(3.7±0.6)scores respectively](P< 0.05),and non-ache days during treatment[(11±4)days]were more than thosebefore treatment[(8±3)days](P< 0.05).The effects of flunarizine were superior to nimodipine(P< 0.05).In the flunarizine group,the plasma levels ofβ-EP and cGMP[(29.03±5.45)ng/L and(2.84±0.86)ng/L respectively]were increased significan

关 键 词：偏头痛 氟桂嗪 尼莫地平 

分 类 号：R441.1[医药卫生—诊断学]