EMT模型大鼠在位和异位子宫内膜的超微结构变化  

The ultrastructural change of eutopic and ectopic endometrium from EMT model rats

作　　者：徐邦生[1] 张天一[2] 林琳[2] 黄晓春[2] 

机构地区：[1]南通大学组织胚胎学教研室,南通226001 [2]南通大学分析细胞学研究室,南通226001

出　　处：《南通医学院学报》2004年第4期370-372,共3页ACTA Academiae Medicinae Nantong

基　　金：江苏省普通高校自然科学研究计划资助项目 (0 2 KJD2 10 0 0 1)

摘　　要：目的 :观察子宫内膜异位症 (endometriosis,EMT)模型大鼠造模早期在位和异位子宫内膜的超微结构变化 ,探讨机体对异位组织的自行清除作用。方法 :建立大鼠 EMT动物模型 ,取 2、4、6、8、10、12天模型大鼠在位和异位子宫内膜制作电镜标本 ,观察腺上皮细胞、基质细胞、巨噬细胞等固有层中细胞的形态变化。结果 :造模后在位内膜结构基本正常。 2～ 8天模型大鼠异位内膜中可观察到的凋亡腺上皮细胞 ,基质细胞渐多 ,部分细胞表现为坏死。第 8天见凋亡的巨噬细胞。 10～ 12天模型大鼠异位内膜中见腺上皮增生 ,固有层中见较多的嗜酸性粒细胞。结论 :异位内膜有被机体自行清除和异位存活两种可能性。Objective:To observe the ultrastructural change of eutopic and ectopic endometrium from EMT model rats and to explore the fate of the ectopic endometrium in woman with endometriosis.Methods:Firstly, to reproduce rat endometriosis model. Secondly, eutopic and ectopic endometrium were acquired for transmission election microscopic examination on the 2 nd、4 th、6 th、8 th、10 th、12 th day after operation.Results:In comparison with the eutopic, atrophy of the uterine glands in ectopic endometrium was commonly seen.With the time extending, apoptosis of glandular cells, stroma cells and macrophages were increased. In some endometrium, necrotic cells and altered organelles were seen,but hyperplasia of the glandular epithelium in ectopic endometrium was observed in the 10 th～12 th day after operation.Conclusion:Ectopic endometrium may develop in two possible directions: eliminated by apoptosis or necrosis and survived.

关 键 词：子宫内膜异位模型 大鼠 超微结构 

分 类 号：R711.71[医药卫生—妇产科学]