人FGF-1对免疫系统的影响  

The Regulating Roles of Human Acid Fibroblast Growth Factor in the Immune System

作　　者：刘华伟[1] 李校堃[1] 赵勇[2] 

机构地区：[1]暨南大学医药研发中心,广州510632 [2]中国科学院动物所生物膜与膜生物工程国家重点实验室移植生物学研究组,北京100080

出　　处：《中国生物工程杂志》2004年第11期1-4,共4页China Biotechnology

基　　金：国家重大基础研究规划(973)资助项目(G1999054204);国家863计划资助项目(2001AA215030);国家自然科学基金面上与重点资助项目(30170966;30230370)

摘　　要：酸性成纤维细胞生长因子 (acidfibroblastgrowthfactor,aFGF或FGF 1 )是成纤维细胞生长因子家族成员之一 ,是一种重要的生长因子。人FGF 1 (FGF 1 )是一个 1 7～ 1 8kDa的非糖基化多肽 ,三胚层来源的细胞都可以表达。FGF 1的生物学效应非常广泛 ,在组织和器官发育、血管发生、血细胞生成、肿瘤发生、伤口愈合等方面发挥重要的作用。FGF 1对人体的免疫系统也有重要的影响 ,能提高多种刺激诱导的T细胞增殖、凋亡及细胞因子的产生。主要概述了FGF 1的生物学效应、对免疫系统的影响及其潜在的临床应用价值。Acid fibroblast growth factor (aFGF or FGF-1) is a 17～18kDa nonglycosylated polypeptide that is expressed by a variety of cells from all three germ layers.It is a member of FGFs and has extensive biological functions in organ and tissue development,angiogenesis,hematopoiesis,tumorigenesis and wound healing.FGF-1 also has an important effect in immune system.FGF-1 could significantly enhance the proliferation,apoptosis and cytokine production of T cells caused by antigen stimulation in mice and humans.The effects of human FGF-1 on immune responses,its relationship with chronic immune diseases and the potential clinical application of FGF-1 were summarized.;

关 键 词：FGF 免疫系统 生物学效应 影响 临床应用价值 三胚层 血细胞生成 器官发育 糖基化 多肽 

分 类 号：Q427[生物学—神经生物学] R651[生物学—生理学]