妊娠晚期胎羊腹主动脉注射微球建立的胎儿窘迫动物模型  

Animal Model of Fetal Distress in the Fetal Sheep After Injected Microsphere into Fetal Abdominal Aorta

作　　者：周光兴[1,2] 杨幼明[1,2] 李笑天[1,2] 时浩[1,2] 吕美铭[1,2] 赵为之[1,2] 朱萍妹[1,2] 

机构地区：[1]上海医科大学实验动物部 [2]上海医科大学附属妇产科医院

出　　处：《中国实验动物学杂志》1998年第3期129-134,共6页Chinese Journal of Laboratory Animal Science

摘　　要：以妊娠晚期绵羊为研究对象，通过进宫腔手术的方法，从胎羊股动脉插管达腹主动脉（ＡｂｄｏｍｉｎａｌＡｏｒｔａ，ＡＯ）水平，留置导管于胎羊体内，导管经三通管接压力换能器及电磁流量计，连续动态监测胎羊ＡＯ血压，定时抽血作血气分析。手术后经胎羊ＡＯ少量多次注射微球悬液，通过脐动脉进入胎盘阻塞胎盘－胎儿循环，从而建立胎儿窘迫动物模型。通过胎羊血气分析及组织学检查，结果表明：注射微球能够阻塞胎盘，影响胎儿血气和酸碱度的变化，造成一系列符合胎儿窘迫的临床表现。In trauterine surgery were performed at 116-125 gestational days in 16 ewes for the insertion of vesicular catheters at fetal abdominal aorta from femoral artery or shin artery,to build an animal model of fetal distress induced by injected microsphere 0.5ml into the vesicular catheter of fetal abdominal aorta once per 15 minutes.The results indicated that many microspheres appeared in small artery of placenta,two placental tissues around vesicular which was blocked with microsphere was showed degeneration and necrosis.Brain tissue in test group showed acute pathologic changes of degeneration and necrosis.It was suggested that injection of microsphere from fetal abdominal aorta can model the process of fetal distress,and companying neural damaged.

关 键 词：胎羊 注射 腹主动脉 胎儿窘迫 微球 动物模型 血气分析 绵羊 酸碱度 股动脉插管 

分 类 号：Q949[生物学—植物学] R714[医药卫生—妇产科学]