NOD小鼠糖尿病病症的初步观察  

The Observation of the Diabetic Onset of NOD Mouse Strain

作　　者：蒋虹[1] 王艳蓉[1] 张永蓉[1] 汪歌[1] 

机构地区：[1]中国医学科学院中国协和医科大学实验动物研究所

出　　处：《中国实验动物学杂志》1998年第3期157-159,共3页Chinese Journal of Laboratory Animal Science

摘　　要：对１２６只ＮＯＤ小鼠自发性糖尿病发病情况观察，５２周后雌性发病率为５０％，雄性发病率为２８．３％。雌性发病早于雄性，发病期小鼠尿糖、血糖水平升高，发病后２～５周死亡。mice of NOD inbred strain were observed for their diabetes from 3 to 52 weeks old.Total cumulative diabetes incidence in males was 28.3%,lower than that 50% in females Abrupt onset occurred among 10-33 weeks old,while male's onset was later than female's After 45 weeks old,few onset individuals could be found.The diabetic animals died within 2-5 weeks after the onset.Clinical features of the affected animals were glycosuria,hyperglycetemia,polydipsia,polyuria,polyphagia and body weight loss.Severe lymphocytic infiltration in the pancreatic islet was observed in prediabetic and diabetic animals.Insulin dependent diabetes mellitus (IDDM) of NOD mice was an autoimmune disease.NOD mice could be used as a model for human IDDM.

关 键 词：发病期 NOD小鼠 观察 自发性糖尿病 病后 胰岛炎 血糖水平 病症 雄性 雌性 

分 类 号：Q959[生物学—动物学] R587.1[医药卫生—内分泌]