健康免疫状态家兔接种HCMV AD_(169)株死亡原因的初步探讨  

A Preliminary study on the Death of Rabbits Caused by Human Cytomegalovirus(HCMV) AD 169

作　　者：孟红[1,2] 刘菊华[1,2] 孙得刚[1,2] 孙广莲[1,2] 李焱[1,2] 吴惠联[1,2] 郭进林[1,2] 

机构地区：[1]山东省医学科学院基础医学研究所微生物室 [2]山东省千佛山医院病理科

出　　处：《中国实验动物学杂志》1998年第3期166-169,共4页Chinese Journal of Laboratory Animal Science

基　　金：山东省自然基金

摘　　要：本研究将人巨细胞病毒ＡＤ１６９株以１０３ＴＣＩＤ５０接种于新西兰兔后，５～２０ｄ内动物死亡３３．３３％。将死亡动物可疑器官作病理学检查发现，早期死亡动物双肺广泛充满浆液性渗出物，稍后死亡动物肺脏肺泡壁增厚，尘细胞增多，伴有不同程度渗出性病变，肝脏、肾脏出现灶状变性坏死灶，人巨细胞病毒抗原定位检测在上述受到损伤的组织细胞中查到ＨＣＭＶ特异抗原，表明人巨细胞病毒感染家兔造成的肺脏、肝脏、肾脏的严重损害。Rabbits were inoculated with HCMV AD 169 and 33.3% of them died within 5-20days.It was found that lungs were full of serous infiltration,the wall of pulmonary alveolus thickened,MФ increased,liver and kidney appeared necrosis focuses.HCMV antigen was detected in injured tissuses by immunohistochemistry technique.The results suggest that there is a significant correlationship between the injuring of tissues and the death of Rabitts.

关 键 词：死亡 HCMV 人巨细胞病毒 肺脏 肾脏 肝脏 免疫状态 动物 家兔 接种 

分 类 号：Q958[生物学—动物学] R373[医药卫生—病原生物学]