辛伐他汀对高脂血症患者颈动脉内膜-中层厚度及凝血系统的影响  

Effect of simvastatin on intima-media thickness of common carotid artery and coagulative system in hyperlipidemic patients

作　　者：周泉[1] 杨瑜莹[1] 

机构地区：[1]解放军第451医院心血管内科,陕西西安710054

出　　处：《第四军医大学学报》2004年第23期2167-2168,共2页Journal of the Fourth Military Medical University

摘　　要：目的 :观察辛伐他汀对高脂血症患者颈动脉内膜 中层厚度 (IMT)及凝血系统的变化及其非调脂作用 .方法 :高脂血症患者 4 6例口服辛伐他汀 2 0mg ,Qd ,12wk ,分别于治疗前后观察IMT、血脂总胆固醇 (TC)、三酰甘油 (TG)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C)、纤维蛋白原 (FIB)、凝血酶原时间 (TT)、活化部分凝血酶时间(APTT)、凝血酶原时间 (PT)改变 .结果 :血脂紊乱组治疗 12wk后的颈动脉IMT变薄 (P <0 .0 0 1) ;TC ,TG ,LDL C ,FIB均有显著降低 (P <0 .0 0 1) ,HDL C升高 (P <0 .0 0 1) ,TT ,APTT均有显著延长 (P <0 .0 0 1) .PT升高 (P <0 .0 0 1) .结论 :调脂作用的辛伐他汀有效调脂同时可发挥其非调脂作用 ,干预、延迟颈动脉IMT的进程 ,改善凝血系统 ,减低血液黏稠度 .AIM: To observe the nonlipid-lowering effect of simvastatin on the intima-media thickness(IMT)and coagulative system in hyperlipidemic patients. METHODS: Forty-six hyperlipidemic patients were given simvastatin 20 mg, qd for 12 weeks and the changes of TC, TG, LDL-C, HDL-C, IMT, fibrinogen (FIB), thrombin time (TT), activated partial thromboplastin time (APTT) and prothrombin time (PT) were observed. RESULTS: TC, TG, LDL-C, FIB decreased significantly (P<0.001) in hyperlipidemic patients after 12 weeks and IMT also decreased significantly (P<0.001). HDL-C and PT increased significantly (P< 0.001) and so did TT and APTT(P<0.001). CONCLUSION: Simvastatin has both lipid-lowering and nonlipid-lowering effect, which decreases the IMT of the common carotid arteries and improves the coagulative system.

关 键 词：辛伐他汀 颈动脉 内膜-中层厚度 血液凝固 

分 类 号：R543[医药卫生—心血管疾病]