尿α1-微球蛋白对术后早期移植肾功能监测的研究  

Significance of urine α1-microglobulin in monitoring implants function during early stage of kidney transplantation

作　　者：李智刚[1] 王建平[1] 陈立中[2] 

机构地区：[1]武警广东总队医院外三科,广州510507 [2]中山大学医学院附一院器官移植中心,广州510000

出　　处：《武警医学》2004年第11期819-822,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的　尽早发现移植肾功能损害 ,及时处理以提高肾移植成功率。方法　对 5 6例尸体肾移植患者早期进行尿α1-微球蛋白测定 ,依据术后住院期间肾功能恢复情况进行分组 ,并与健康人做比较。结果　急性排斥组较肾功能稳定组α1-微球蛋白高 4倍 (P<0 .0 5 ) ;较健康组高 2 0倍 (P<0 .0 1)。结论　在移植肾功能损害尤其是急性排斥反应时 ,尿α1-微球蛋白能及早反映其存在并指导及时处理。Objective To advance the success rate of kidney transplantation by finding the damage of transplanted kidney at early stage and treating it promptly.Methods The α1-microglobulin levels in urine were determined 56 patients having undergoing kidney transplantation and compared with serum creatinine levels.Results The urine α1-microglobulin concentration in acute rejection group was 4 times higher than that in the stable kidney function group.Conclusion α1-microglobulin is a sensitive and promising parameter in reflecting the function of kidney.

关 键 词：尿Α1-微球蛋白 移植肾 肾功能损害 术后早期 监测 住院期间 急性排斥 结论 指导 情况 

分 类 号：R699.2[医药卫生—泌尿科学] R692[医药卫生—外科学]