手性单双糖Schiff碱的合成及抑菌活性研究  

Study on the synthesis and antibacterial activity of chiral Schiff base from monosaccharide or disaccharide

作　　者：郭应臣[1] 卓立宏[1] 党元林[1] 陈建国[1] 

机构地区：[1]南阳师范学院化学系,河南南阳473061

出　　处：《化学研究与应用》2004年第6期819-821,共3页Chemical Research and Application

基　　金：河南省教育厅自然科学基金资助项目(20021500008);河南省科技厅自然科学基金资助项目(311021900)

摘　　要：多糖、寡糖、Schifr碱及其配合物具有抗癌、抗病毒、杀菌等生物活性。酰肼类化合物可与生物体中的微量元素作用达到抗结核和抗肿瘤效果。在酰肼Schiff碱分子中引入单双糖分子，不仅可增加水溶性，降低毒性，引入手性源，Four new monosaccharide or disaccharide hydrazine Schiff bases were synthesized from D-glucose,lactose,and hydrazines by liquid phase reactions.The products were characterized by elemental analysis,IR,ESI-MS and ()~1H NMR.The results,based on indexing the cell parameters of XRD,show that they belong to monoclinic or triclinic system and that these new schiff bases are some what soluble,and have optical rotation and selective antibacterial activity.

关 键 词：单双糖 SCHIFF碱 合成 手性 抑菌活性 

分 类 号：O629.1[理学—有机化学]