雄激素与老龄雄性大鼠动脉粥样硬化的相关性研究  

Correlation between androgen and atherosclerosis in aged male Wistar rats

作　　者：李丕宝[1] 于桂兰[2] 楮熙[2] 

机构地区：[1]山东省交通医院心内科,250031 [2]山东省立医院干部保健科

出　　处：《疑难病杂志》2004年第6期323-325,F003,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：山东省卫生厅资助项目 (项目编号CARBB4)

摘　　要：目的　研究老龄雄性Wistar大鼠雄激素 (睾酮 ,T)与动脉粥样硬化 (AS)的关系 ,评价雄激素在AS发病中的地位和作用。方法　老龄 (≥ 2 4月龄 )雄性Wistar大鼠 30只 ,随机等分为 3组 :A组为正常对照组 ,进普通饲料 ;B组行高脂饲料喂养 ;C组高脂饲料喂养并加用小剂量雄激素制剂肌肉注射。实验前后检测血清T及血脂 ,并行统计学分析 ,实验结束后取大鼠主动脉标本 ,行电镜检查 ,结合电镜图像比较各组大鼠主动脉形态及结构的差异。结果　各组实验前后比较 :B组实验后血清总胆固醇(TC)、甘油三酯 (TG)明显高于实验前 (P <0 .0 1) ;C组实验后TC、TG(P <0 .0 5 )及T(P <0 .0 1)均明显高于实验前。实验后的各组间比较 :B组大鼠血清TC、TG与A组相比明显增高 (P <0 .0 1) ,C组大鼠血清T与A组相比亦明显升高 (P <0 .0 1) ;C组与B组相比 ,血清T值明显升高 (P <0 .0 1) ,TC、TG明显降低 (P <0 .0 1)。电镜图像显示 ,B组AS程度最重 ,C组AS程度显著轻于B组。结论　雄激素能对抗AS ,并可能有降低TC、TG的作用 ,低雄激素血症可能为老龄男性AS及冠状动脉疾病 (CAD)的独立危险因素。Objective To investigate the correlation betwee n testosterone and atherosclerosis(AS) in the aged male Wistar rats.Meth ods Thirty aged male Wistar rats were randomly divided into three grou ps.In group A rats were fed with normal diet as control group.In group B rats we re fed with high-fat diet.While in group C high-fat diet combined with androge n injection was given.The serum testosterone and blood lipid levels were measure d and analyzed by statistical method.The morphological and structural changes of aorta were detected by electroscope.Results In group B serum t otal cholesterol and triglyceride levels increased (P<0.01),but serum testo sterone levels had no significant difference,as compared with those of pre-expe riment.In group C the serum total cholesterol, triglyceride and testosterone lev els also increased,as compared with those of pre-experiment(P<0.05 or P <0.01).As compared with those of the control group,serum total cholesterol an d triglyceride levels increased (P<0.01).However,testosterone levels were n ot changed after high-fat diet in group B.Serum testosterone levels increased i n group C(P<0.01).The serum testosterone levels in group B was higher and s erum total cholesterol and triglyceride levels were lower than those in group C (P<0.01).The degree of atherosclerosis in group C was less serious than th at in group B according to electroscope image .Conclusion Andro gen may prohibit the genesis and development of AS,perhaps which can help to re duce the serum total cholesterol and triglyceride levels.Hypoandrogenism is an i ndependent risk factor of atherosclerosis and coronary artery disease in elderly men.

关 键 词：雄激素 老龄 血清 大鼠 TG TC 实验 降低 

分 类 号：R543.5[医药卫生—心血管疾病]