肾移植术后早期急性排斥反应与HLA误配  

The early rejection and HLA-A,B,DR mismatching of kidney transplantation

作　　者：尔秀江[1] 解泽林[1] 杜林栋[1] 马威然[1] 毕如玫[1] 

机构地区：[1]首都医科大学附属北京友谊医院泌尿科,北京100050

出　　处：《临床和实验医学杂志》2004年第4期197-199,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的　研究组织相容性白细胞抗原 (HLA)配型与肾移植术后早期急性排斥反应的关系。方法　将 12 86例次肾移植受者 ,按HLA误配率 (MM )进行分组 ;统计各组术后 1～ 2个月内急性排斥反应的发生状态。结果　HLA配型 6误配组 ,术后早期急性排斥反应发生率为 2 1 3 % ;5误配组为 2 9 8% ;4误配组为 19 3 % ;3误配组为 16 0 % ;2误配组为 12 0 % ;1和 0误配组未见术后早期急性排斥反应发生。结论　供—受者间HLA配型愈好 ,即误配率愈低 ,肾移植术后早期发生急性排斥反应的危险性愈低。Objective To study the relationship between HLA typing and early rejection after kidney transplantation. Methods The 1286 recipients undergoing kidney transplantation were randomly grouped in terms of the HLA mismatching frequency (MM).The incidence of early rejection 1～2 months after operation was analyzed. Results The incidences of postoperative acute rejection were 21.3%,29.8%,19.3%,16%,and 12% in patients with 6MM,5MM,4MM,3MM,and 2MM respectively,Postoperative acute rejection was not observed in patients without mismatching and patients with only one mismatching. Conclusion The result suggested that HLA matching frequency may determined the incidence of acute rejection.

关 键 词：肾移植 HLA抗原 移植物排斥 

分 类 号：R699[医药卫生—泌尿科学]