医院获得性下呼吸道感染致病菌对抗菌药物的耐药性调查  

Antimicrobial Resistance of Pathogens in Nosocomial Respiratory Tract

作　　者：于翠香[1] 傅爱玲[1] 阎申[1] 刘学梅[1] 宁康[1] 周玲[1] 石彦明[1] 刘世清[1] 

机构地区：[1]山东省千佛山医院,济南250014

出　　处：《中华医院感染学杂志》2004年第12期1415-1417,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解医院感染菌的分布及耐药情况,指导经验性治疗抗菌药物的临床应用。方法采用符合医院获得性肺炎患者痰标本分离的致病菌株,用琼脂扩散法测定其对12种抗菌药物的敏感性。结果共检验出致病菌269株,革兰阴性菌182株;其中鲍氏不动杆菌、大肠埃希菌、铜绿假单胞菌、嗜麦芽寡养单胞菌、肺炎克雷伯菌占前5位;革兰阳性菌87株,以金黄色葡萄球菌占大多数;药敏显示革兰阴性菌、阳性菌分别对亚胺培南、万古霉素最敏感。结论医院感染菌的多重耐药给抗菌治疗带来困难,检测细菌分布及耐药性变化具有重要意义。OBJECTIVE To study the distribution and the drug resistance situation of bacteria isolated from inpatients and then to guide the experienced application of antibacterial agents. METHODS Agar diffusion method was used to determine the susceptibility to 12 kinds antibacterial agents of bacteria isolated from the hospital acquired pneumonia(HAP) patients′ sputum samples. RESULTS A total of 269 pathogenic strains were tested, including 182 strains of Gram negative bacilli and 87 strains of Gram positive cocci. Among Gram negative bacilli, the first 5 strains were Acinetobacter baumannii , Escherichia coli, Pseudomonas aeruginosa , Ctenotrophomonas maltophilia and Klebsiella pneumoniae. However, The most Gram positive cocci were Staphylococcus aureus . The microbial sensitivity test displayed the Gram negative bacilli were the most sensitive to imipenem and the Gram positive cocci were the most sensitive to vancomycin. CONCLUSIONS The multidrug resistance of bacteria isolated from inpatients is the difficulty to antibacterial treatment, then inspecting the distributing and the drug resistance changes of bacteria is important.

关 键 词：医院获得性下呼吸道感染 病原菌 抗菌药物 耐药性 

分 类 号：R969.3[医药卫生—药理学]