益脉降压流浸膏对老年Ⅱ期原发性高血压患者胰岛素抵抗的影响(英文)  

Effect of yimai jiangya liujingao on insulin resistance in patients with senile primary hypertension II

作　　者：段学忠[1] 钟慎清 蔡新吉[1] 杨丁友[1] 

机构地区：[1]解放军济南军区总医院中医科,山东省济南市250031 [2]阳谷县中医医院内科,山东省阳谷县252300

出　　处：《中国临床康复》2004年第36期8413-8415,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:原发性高血压患者普遍存在胰岛素抵抗(insulinresistance,IR),因而增加了发生冠心病的危险性,中药制剂对原发性高血压患者IR的水平有何影响?目的:探讨中药制剂益脉降压流浸膏对老年气虚血瘀证型Ⅱ期原发性高血压患者IR的影响。设计:病例-对照研究。地点和对象:治疗组(n=40)来源于济南军区总医院符合1999年世界卫生组织制定的高血压诊断标准,同时符合中国中西医结合研究会制定的中医虚证辨证标准及血瘀证诊断标准辨证属气虚血瘀证型的高血压患者,对照组(n=30)为同期来济南军区总医院健康体检者,无原发性高血压、糖尿病等疾病。实验指标测定在济南军区总医院中心实验室进行。干预:治疗组口服益脉降压流浸膏(药物组成:生黄芪、党参、黄精、当归、川芎、生蒲黄、穿山龙等,每毫升含生药2.0g,由山东济南宏济堂制药有限责任公司提供,批号:991218),10mL/次,3次/d。疗程为8周。分别采用葡萄糖氧化酶法及放射免疫法测定治疗组治疗前后的空腹血糖、空腹血浆胰岛素(fastingplasmainsulin,FPI),计算其胰岛素敏感性指数(insulinsensitivityindex,ISI),并与对照组的空腹血糖、FPI、ISI进行比较。结果:治疗组治疗前空腹血糖犤(4.97±0.61)mmol/L犦与对照组比较,差异无显著性意义(t=1.131,P>0.05);FPI犤(13.71±4.BACKGROUND:Since it is commonly present in patients with primary hypertension,insulin resistance (IR) greatly threatens to occurrence of coronary heart disease.How do Chinese herbal preparations affect IR level in patients with primary hypertension?<OBJECTIVE:To probe into the effect of Chinese herbal preparation,yimai jiangya liujingao on IR in patients with senile primary hypertension II of qi deficiency and blood stagnation.<DESIGN:Controlled study on cases.<SETTING and PARTICIPANTS:The cases(n=40) in treatment group were from General Hospital of Jinan Military Area Command of Chinese PLA. They accorded with Diagnostic Standard on Hypertension determined by WHO in 1999,with Differentiating Diagnostic Standard on Deficiency Syndromes in Chinese Medicine and Diagnostic Standard on Blood Stagnation Syndromes determined by China Research Association of Collaboration of Chinese and Western Medicine.The cases of hypertension were diagnosed as qi deficiency and blood stagnation.The cases(n=30) in the control were the people from General Hospital of Jinan Military Area Command of Chinese PLA in the same period.By general health checks,they were absent of primary hypertension and diabetes.The experimental measure determination was performed in Central Experimental Room in General Hospital of Jinan Military Area Command of Chinese PLA.<INTERVENTIONS:In treatment group,yimai jiangya liujingao (Drug composition:shenghuangqi, dangshen, huangjing, danggui, chuanxiong, shen puhuang, chuangshanjia, etc.Each milliliter contains raw herb 2.0 g;provided by Shangdong Jinan Hongjitang Pharmaceuticals Co.Ltd.,No.991218) was taken orally, 10 mL/time,3 times daily and 8 weeks as one course.With glucose oxidase method and radioimmunoassay,fasting blood sugar (FBS) and fasting plasma insulin(FPI) were determined respectively before and after treatment and insulin sensitivity index(ISI) was calculated.The results of FBS,FPI and ISI were compared between the treatment and the control groups.<RESULTS:Compared with the control,the result

关 键 词：高血压 胰岛素抗药性 补气 活血 通络 

分 类 号：R544.1[医药卫生—心血管疾病]