心肌肌钙蛋白I在心脏移植术后恢复及排斥反应中的意义  

Significance of cardiac troponin I in postoperative recovery and acute rejection of heart transplantation

作　　者：王晓武[1] 蔡振杰[1] 胡军[1] 李彤[1] 胡巧侠[1] 单飞[1] 陶开山[1] 

机构地区：[1]第四军医大学西京医院心血管外科中心,西安710032

出　　处：《中华心血管病杂志》2004年第11期989-991,共3页Chinese Journal of Cardiology

摘　　要：目的对19例心脏移植受体术后早期及定期行心肌肌钙蛋白I(cardiactroponinI,cTnI)检测,探讨cTnI在心脏移植术后恢复及排斥反应中的作用。方法(1)对19例心脏移植受体术后1个月内每日行cTnI检测;(2)对存活的心脏移植受体每3个月或发现急性排斥反应时行cTnI检测。结果(1)19例心脏移植术后1个月内恢复顺利的患者其心肌cTnI的下降速度均较快,心脏移植后8天内均下降至10μg/L以下,20天内降至正常,而死亡5例患者中早期死亡的3例其cTnI在术后10天后仍维持在较高水平;(2)14例存活的心脏移植受体定期复查cTnI均正常,其中4例心肌活检病理确诊为Ⅱ级以上急性排斥反应患者,不论出现急性排斥反应的级别高低,其cTnI均未见升高。结论cTnI对心脏移植早期恢复评定具有重要意义,而与急性排斥反应无明显相关性。Objective To explore the significance of cardiac troponin I(cTnI) action in postoperative recovery and acute rejection of heart transplantation. Methods (1) The levels of cTnI in 19 recipients of heart transplantation were measured every day in one month of postoperation; (2) The levels of cTnI were measured every 3 months in alive recipients or measured when recipients was found acute rejection. Results (1) The levels of cTnI decreased rapidly in smoothly recovered recipients, and droped to lower 10 μg/L in 8 and to normal range in 20 days of postoperation, but in 3 dead cases cTnI kept in high level during 10 days of postoperation. (2) In 14 alive recipients cTnI were in normal range showed by regular measurements and it didn′t rise in 4 recipients with acute rejection. Conclusions The change of cTnI seems very important in evaluating early recovery of heart transplantation and may be not related to acute rejection.

关 键 词：cTnⅠ 心脏移植术 急性排斥反应 受体 术后恢复 心肌肌钙蛋白Ⅰ 患者 存活 发现 维持 

分 类 号：R654.2[医药卫生—外科学]