褪黑素对鼠心肌缺血再灌注后血流动力学的影响  

Effects of Melatonin on Isolated Rat Myocardial Blood Stream Dynamics after Ischemic-Reperfusion

作　　者：袁媛[1] 龙村[1] 关彬[2] 史世勇[2] 温福兴[1] 张燕婉[2] 

机构地区：[1]阜外心血管病医院体外循环科,北京100037 [2]阜外心血管病医院麻醉体外循环研究室,北京100037

出　　处：《中国体外循环杂志》2004年第4期211-213,216,共4页Chinese Journal of Extracorporeal Circulation

基　　金：卫生部"十五"攻关课题 (2 0 0 2 - 1 5 0 3)

摘　　要：目的　探讨不同浓度褪黑素预处理对成年大鼠心肌缺血 -再灌注 (I/R)后血流动力学的影响。方法　 32只成年S -D大鼠 (35 0 4 0 0g)随机分为 4组 ,每组 8只 ,利用Langendorff模型灌注其离体心脏 ,待心脏功能稳定后 ,对照组平衡 30min后缺血再灌注 ,预处理组则用不同浓度的褪黑素灌注 30min后缺血再灌注。各组均为常温(37℃ )缺血 2 5min ,复灌 6 0min。观察各组血流动力学改变。结果　褪黑素预处理组左心功能恢复明显高于对照组。结论　褪黑素预处理促进成年大鼠心肌缺血 -再灌注 (I/R)后血流动力学恢复。OBJECTIVE To investigate the protective effects of Melatonin on post-ischemic blood stream dynamics in isolated Sprague-Dawley rat myocardium.METHODS 32 adult Sprague-Dawley rats (350~400g) were randomly divided into 4 groups. Hearts were subjected to 25 min of normothermic global ischemia followed by 60 min of reperfusion.RESULTS Duration of ventricular arrhythmia significantly decreased and LVDP, ±dp/dtmax recovery had a significant improvement in melatonin pretreatment groups. CONCLUSION Melatonin is an effective agent for protection against post-ischemic reperfusion injury.

关 键 词：褪黑素 血流动力学 心肌缺血再灌注 对照组 心肌缺血-再灌注 成年大鼠 复明 影响 左心功能 离体心脏 

分 类 号：R654.1[医药卫生—外科学]