老年混合性高脂血症药物联合治疗的临床观察  

The observation of combinative therapy of mixed hyperlipidemia in the elderly

作　　者：郭晓斌[1] 谭秀娟[1] 张福春[1] 

机构地区：[1]北京大学第三医院老年内科,100083

出　　处：《实用老年医学》2004年第6期298-299,307,共3页Practical Geriatrics

摘　　要：目的　 探讨在老年患者中调脂药物低剂量联合应用的有效性、安全性。　 方法　辛伐他汀或吉非贝齐单一药物治疗 98例混合性高脂血症患者 4周 ;选择血脂指标未全面达到正常标准者 41例 ,应用低剂量药物联合治疗 ,疗程为 12周。采用自身前后对照 ,观察 2种方案总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的达标率及不良反应发生率等方面差异。　 结果　联合治疗后患者的各项血脂指标均得到了不同程度地调控 ,达标率为 60 98% ,仅 1例出现不良反应。　 结论　他汀类和贝特类的低剂量联合应用能够安全地、更全面、更有效地调节混合性高脂血症患者的血脂紊乱。Objective To evaluate the efficacy and safety of lipid-lowering combinative therapy in the elderly. Methods Ninety-eight mixed hyperlipidemia patients were treated with simvastatin or germfibrate for 4 weeks;41 patients out of the 98,whose serum lipids did not reach advised level,were treated with low-dosage lipid-lowering combinative therapy for another 12 weeks.The levels of serum TC,TG,HDL-C,LDL-C,the ratio of up to advised level and side-effects between these two protocols were observed. Results After combinative therapy,serum lipids of these 41 cases all improved,the ratio of up to advised level being 60.98% and with only 1 case having adverse events. Conclusions Statins combined with fibrates in low-dosage is safer and more effective in elderly who have mixed hyperlipidemia.

关 键 词：高脂蛋白血症V型 辛伐他汀 吉非贝齐 老年人 

分 类 号：R589.2[医药卫生—内分泌]