Cpn慢性感染与老年呼吸道疾病的血清学相关性研究  

Serological study of an association between chronic Chlamydia pneumoniae infection and respiratory tract diseases in the elderly

作　　者：陈延斌[1] 陶岳多[1] 凌春华[1] 黄建安[1] 朱蓉梅[1] 

机构地区：[1]苏州大学附属第一医院呼吸科,215006

出　　处：《实用老年医学》2004年第6期303-304,307,共3页Practical Geriatrics

摘　　要：目的　观察肺炎衣原体 (Cpn)慢性感染与老年呼吸道疾病相关的血清学证据。　 方法 　采用间接免疫荧光法检测Cpn特异性抗体IgA、IgG、IgM。　 结果 　老年组、非老年组和健康对照组的慢性感染率分别为60 .0 %、3 3 3 %和 2 0 4% ,既往感染率分别为 71 1%、48 3 %和 47 2 % ,差异均具有显著性 (均为P <0 0 1)。在慢性感染方面 ,老年组和非老年组间、老年组和健康对照组间差异有显著性 (均为P <0 0 1) ;非老年组和健康对照组间差异无显著性 (P >0 0 5 ) ;在既往感染方面 ,3组的统计结果同慢性感染相一致。　 结论 　Cpn是老年呼吸道感染的重要病原菌之一 ,Cpn慢性感染与老年人肺癌、慢性阻塞性肺疾病 (COPD)等密切相关。Objective To investigate the association of chronic chlamydia pneumoniae infection with respiratory tract diseases in the elderly. Methods Chlamydia pneumoniae specific serum IgA,IgG,IgM antibodies were measured by the titerplane technique developed by Euroimmun and microimmunofluorescence test. Results None of all detected samples was diagnosed as acute infection.The chronic infection rate of aged group,young group and healthy control group were 60.0%,33.3%,20.4% respectively,while the past infection rate of the three groups were 71.1%,48.3%,47.2% respectively.There were statistical significances among the three groups in terms of the chronic and past infection rate (P<0.01).As to the chronic infection ,there were strong statistical significances between aged group and young group,as well as between aged group and healthy control group (P<0.01),no statistical significance was found between young group and healthy control group (P>0.05).As to the past infection,the statistical results of the three groups complied with the chronic infection’s. Conclusions Chlamydia pneumoniae was one of the most important pathogens of respiratory tract infection in the elderly.Chlamydia pneumoniae infection,first of all,the chronic infection was universal in the elderly patients.There were significant relationships between chronic infection of chlamydia pneumoniae and lung cancer,as well as chronic obstructive pulmonary disease (COPD).

关 键 词：衣原体 肺炎 呼吸道感染 免疫球蛋白类 老年人 

分 类 号：R563.1[医药卫生—呼吸系统]