孕妇血清HBV-DNA含量对预测胎儿宫内感染的临床价值  

Clinical value of serum HBV-DNA content for measuring intrauterine fetal infection

作　　者：刘虹[1] 吴婉林 陈丽[1] 扬东文 

机构地区：[1]贵州省贵阳市妇幼保健院,550003

出　　处：《中国妇幼保健》2004年第12期52-53,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨孕妇血清HBV-DNA含量对预测胎儿宫内感染的临床价值。方法:应用聚合酶链反应(PCR)法检 测103例乙型肝炎表面抗原(HBsAg)阳性孕妇的血清HBV-DNA含量,并对相关因素进行分析。结果:103例HBsAg阳性孕妇 的HBV-DNA检出阳性率为56%,胎儿宫内感染率为12.6％,且胎儿宫内感染率随血清HBV-DNA含量的增加而升高, HBV-DNA含量与胎儿宫内感染率呈正相关(r=0.572,P<0.01)。结论:孕妇血清HBV-DNA含量可间接预测胎儿宫内感染 的发生率。Objective: To study the clinical value of serum HBV-DNA content for measuring intrauterine fetal infection. Methods: Polymerase chain reaction (PCR) was used to measure serum HBV-DNA content in 103 HBsAg positive pregnant woment, and the results are analyzed. Results: The positive rate of HBV-DNA was 56%, intrauterine fetal infection rate was 12. 6% , and the rate of fetal intrauterine infection was increasing with the increase of serum HBV-DNA content. Conclusion: Fetal intrauterine infection was relative with serum HBV-DNA content of pregnant women.

关 键 词：乙型肝炎病毒 宫内感染 胎儿 DNA 

分 类 号：R714.251[医药卫生—妇产科学]