高温联合辐射对孕鼠胚胎神经系统发育的影响  

Effects of high temperature and irradiation on the development of nervous system in early rat embryos

作　　者：刘慧娟[1] 贾德永[2] 丰慧根[1] 李延兰[1] 林俊堂[1] 

机构地区：[1]新乡医学院细胞生物教研室 [2]新乡医学院组胚教研室,河南新乡453003

出　　处：《新乡医学院学报》2005年第1期11-12,共2页Journal of Xinxiang Medical University

基　　金：河南省自然科学基金资助项目(9745020500)

摘　　要：目的探讨高温与辐射(γrays)联合对大鼠胚胎神经系统发育的影响。方法用高温联合γrays处理孕8～10d的大鼠,于18d处死。按致畸实验方法观察胚胎神经系统的发育。结果41℃组和42℃组神经管未闭、体节异常和脑形态异常与高温温度及持续时间呈正相关(P<0.01)。41℃高温持续4min和42℃高温与辐射联合作用,其胚胎神经系统异常发生率明显高于单独高温作用(P<0.01)。Objective To study if high temperature and irradiation could produce combined effects on the development of nervous system in early rat embryos.Methods Pregnant rats at the 8～11 d of gestation was exposed to high temperature combined with γ-irradiation(1.0Gy,~60 Co-rays).The indexes of embryonic nervous system development were determined with teratogenisity experiment.Results Along with increased temperature,all indexes,cluding dysraphia and abnormal somite and encephalic configuration,correlated with hyperthermy and hyperthermal time.With an apparent time-effect relationship(P<0.01).And the nervous system development and morphological differentiation induced by both high temperature and ~60 Co-rays were higher than that by high temperature alone(P<0.01).Conclusion The development of nervous system of rat on 8～10 week of gestatimal age is markedly influenced by the hyperthermy and γ-ray irradiation.The development of embryonic nervous system and morphological difference were increased by the effect of the high temperature combined with ~60 Co-rays on pregnant rats.

关 键 词：高温 辐射 胚胎 神经系统 

分 类 号：Q954.48[生物学—动物学]