缬沙坦对急性心肌梗死后左室重塑的影响  

Effect of Valsartan on Ventricular Remodeling in Patients with Myocardial lnfarction

作　　者：邵斌[1] 袁琦[2] 

机构地区：[1]郑州大学第三附属医院药械科,郑州市450052 [2]河南省人民医院药剂科,郑州市450003

出　　处：《医药论坛杂志》2004年第23期20-21,23,共3页Journal of Medical Forum

摘　　要：目的　观察缬沙坦对急性心肌梗死后左室重塑的影响。方法　将 6 4例急性心肌梗死患者随机分为常规治疗组 32例、缬沙坦治疗组 32例 ,并于急性心肌梗死后 2周、2 4周分别进行超声心动图和平衡法核素心室造影 ,测定左室心肌重量、左室收缩功能和舒张功能 ,了解缬沙坦对急性心肌梗死后左室重塑的影响。结果　AMI后 2 4周时缬沙坦组与常规治疗组比较室间隔厚度、左室后壁厚度、左室舒张末内径和左室心肌重量指数均明显降低。急性心肌梗死后 2 4周时缬沙坦治疗组与对照组比较左室射血分数明显增加 ,左室峰射血率时间下降。结论　缬沙坦能明显减轻心肌梗死后心肌肥厚和左室重塑 ,改善左室功能。Objective To investigate the effect of valsartan on ventricular remodeling in patients with acute myocardial infarctions(AMI). Methods 64 cases with AMI were divided into two groups randomly.The valsartan group(regular treatment group 32 cases,the valsartan treatment group 32 cases. Echocardiography and gated blood pool scanning were performed at 2 and 24 weeks after AMI to compare the ventricular remodeling in the two groups.Results 24 weeks after AMI, the left ventricular remodeling in the valsartan group were significantly lower than that of the control group.Coclusion valsartan may inhabit myocardial hypertrophy and left ventricular remodeling after AMI improve left ventricular function.

关 键 词：重塑 左室 急性心肌梗死 缬沙坦 

分 类 号：R542.2[医药卫生—心血管疾病]