含1,2,4-三唑基和肟醚基的N-甲氧基氨基甲酸酯类化合物的合成及杀菌活性  

Synthesis and Fungicidal Activity of N-Methoxylcarbamates Containing 1,2,4-Triazole and Oxime Ether

作　　者：刘卫东[1] 邓义[2] 兰支利[2] 王晓光[1] 高必达[3] 

机构地区：[1]湖南化工研究院国家南方农药创制中心湖南基地,湖南长沙410007 [2]湖南师范大学化学化工学院,湖南长沙410081 [3]湖南农业大学,湖南长沙410128

出　　处：《农药学学报》2004年第4期13-17,共5页Chinese Journal of Pesticide Science

基　　金：国家"十五"科技攻关项目(2004BA308A22)资助;湖南省杰出青年科学基金(04JJ1009)资助.

摘　　要：通过(Z)-1-(取代苯基)-2-(1H-1,2,4-三唑-1-基)乙酮肟与N-甲氧基-N-(2-溴甲基苯基)氨基甲酸甲酯反应,合成了11个新的含有三唑基和肟醚基的N-甲氧基氨基甲酸酯类化合物(V1～V11),其结构均经1HNMR、IR、LC/MS及元素分析确证。对合成的化合物进行了离体抑菌活性实验,结果表明:在50mg/L下,所有化合物对小麦赤霉病菌Gibberellazeae(Schw.)Petch、稻瘟病菌PyriculariaoryzaeCav.和黄瓜灰霉病菌BotrytiscinereaPers.都有一定的抑菌活性,其中V4、V11对稻瘟病菌的抑菌活性分别达96.5%和96.7%,对黄瓜灰霉病菌的抑菌活性分别达到95.9%和90%。Eleven novel N-methoxylcarbamates containing 1,2,4-triazole and oxime ether group were synthesized from (Z)-1-substituted phenyl-2-(1H-1,2,4-triazol-1-yl)-ethanoxime and methyl N-methoxy-N-(2-bromomethylphenyl) carbamates. All compounds were confirmed by (~1H NMR, )IR, LC/MS and elemental analysis. The results of preliminary fungicidal tests in vitro showed that some compounds prossessed fungicidal activities inhibiting Gibberella zeae, Pyricularia oryzae and Botrytis cinerea at the concentration of 50 mg/L. The inhibitory ratio of V_4 and V_(11) against P. oryzae were 96.5% and 96.7%, the ratio against B. cinerea were 95.9% and 90%.

关 键 词：合成 1 2 4-三唑 N-甲氧基氨基甲酸酯 杀菌活性 

分 类 号：O625.632[理学—有机化学]