急进高原对大鼠血浆及肝脏CuZn—SOD、Mn—SOD及LPO的影响  

THE EFFECT OF ENTERING HIGH ALTITUDE RAPIDLY ON CUZN-SOD,MN-SOD ACTIVITIES AND LPO LEVELS IN RAT SERUM AND LIVER

作　　者：刘衍国 张晓林[1] 张惠莉[1] 王珺[1] 唐炜东 白海燕[1] 

机构地区：[1]青海医学院生化教研室

出　　处：《青海医学院学报》1993年第1期15-17,共3页Journal of Qinghai Medical College

摘　　要：将平原大鼠快速带至高原地区后(3800m),其血浆及肝组织中CuZn—SOD及Mn—SOD活力均明显下降(P<0.05,P<0.01)。而LPO含量则显著升高(P<0.01)。SOD的活力下降与LPO含量升高有关。提示,急进高原后,体内自由基生成增多,抗氧化能力减弱,对高原适应不利。SummaryThe activities of CuZn-SOD and Mn-SOD in rat serum and liver decreased significantly(P<0.05,P<0.01),but LPO levels increased significantiy(P<0.01) after carring of rats rapidly from low altitude to high altitude. The increase of LPO levels was responsible for the decrease of SOD activity. The results suggest that the free radicals increase and the antioxidant abilities decrease. These changs are not good for high altitude acclimatization.

关 键 词：高山病 过氧化脂质 超氧物歧化酶 

分 类 号：R594.3[医药卫生—内科学]