一种小鼠慢性炎症性肉芽肿血管生成改良模型  

Murine chronic granulomatous air pouch model for angiogenesis

作　　者：欧阳雪宇[1] 何瑜[1] 白金叶[1] 彭珊瑛[1] 王文杰[1] 

机构地区：[1]中国医学科学院.协和医科大学药物研究所药理室,北京100050

出　　处：《中国药理学通报》2004年第12期1430-1432,共3页Chinese Pharmacological Bulletin

基　　金：国家"8 63"计划资助项目;No 2 0 0 2AA2 3 3 0 81

摘　　要：目的　改良小鼠慢性炎症性肉芽肿血管生成模型。方法　小鼠背部无菌注射空气形成气囊后注入刺激剂诱导慢性肉芽肿血管生成模型 ,采用组织形态学方法检测气囊病理变化 ,通过比色法测定血管指数。结果　诱导的气囊组织呈典型的肉芽组织结构 ,伴有大量毛细血管增生 ,氢化可的松明显抑制血管生成指数。结论　小鼠慢性肉芽肿血管生成模型是一种稳定可靠的慢性炎症性血管生成模型。Aim To develop a modified murine chronic granulomatous air pouch model for angiogenesis. Methods The granulomatous air pouch was induced by Freund's Complete Adjuvant after subcutaneously injection of air into the dorsum of mice. The vascular index was determined by colorimetry of carminic acid. Angiogenesis in granuloma air pouch was observed by histology method. Result The Induced air pouch showed typical granulomatous characteristics, with large amount of newly formed capillary in it; Hydrocortisone remarkablely inhibited the vascular index.Conclusion The murine chronic granulomatousair pouch model has been shown to be suitable for studying chronic inflammatoryangiogenesis since it is easy and reliable.imetryof

关 键 词：血管生成模型 炎症 肉芽肿 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学] R363-332[医药卫生—基础医学]