一种新型含二茂铁基的多吡啶钌配合物与DNA的相互作用  

Interaction Between DNA and a Novel Ferrocenyl-containing Ruthenium(Ⅱ) Polypyridyl Complex

作　　者：韩美娇[1] 王科志[1] 吕媛媛[1] 高丽华[2] 

机构地区：[1]北京师范大学化学系,北京100875 [2]北京工商大学环境与化工学院,北京100037

出　　处：《高等学校化学学报》2004年第12期2221-2223,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 0 3 710 0 8);北京市优秀人才基金资助

摘　　要：A novel ruthenium polypyridyl complex of [Ru(bpy) 2(FcIP)](PF 6) 2(bpy=2,2′-bipyridine, FcIP=2-ferrocenyl-imidazo[4,5-f]-1, 10-phenanthroline) was synthesized and characterized by elementary analysis and 1H NMR. The binding of the complex to calf thymus(ct) DNA was investigated with absorption and luminescence spectroscopy titrations, steady-state emission quenching, and viscosity measurements. The results suggest that the complex acted as a ct-DNA intercalator with an intrinsic binding constant of (2.0±0.4)×10 5 L/mol in buffered 50 mmol/L NaCl.A novel ruthenium polypyridyl complex of [Ru(bpy) 2(FcIP)](PF 6) 2(bpy=2,2′-bipyridine, FcIP=2-ferrocenyl-imidazo[4,5-f]-1, 10-phenanthroline) was synthesized and characterized by elementary analysis and 1H NMR. The binding of the complex to calf thymus(ct) DNA was investigated with absorption and luminescence spectroscopy titrations, steady-state emission quenching, and viscosity measurements. The results suggest that the complex acted as a ct-DNA intercalator with an intrinsic binding constant of (2.0±0.4)×10 5 L/mol in buffered 50 mmol/L NaCl.

关 键 词：DNA 钌(Ⅱ)配合物 二茂铁 

分 类 号：O641.3[理学—物理化学]