新单取代苯磺酰脲衍生物的合成及生物活性  

Synthesis and Biological Activity of New Phenylsulfonylurea Derivatives

作　　者：马宁[1] 李鹏飞[1] 李永红[1] 李正名[1] 王玲秀[1] 王素华[1] 

机构地区：[1]南开大学元素有机化学研究所元素有机化学国家重点实验室

出　　处：《高等学校化学学报》2004年第12期2259-2262,共4页Chemical Journal of Chinese Universities

基　　金：国家"九七三"计划项目 (批准号 :2 0 0 3 CB114 40 6);教育部南开大学;天津大学科技合作基金;天津市自然科学基金重点基金 (批准号 :0 3 3 80 3 411)资助

摘　　要：以较高活性的单取代苯磺酰脲为基础 ,设计合成了 1 4个新的含烷硫基和烷胺基嘧啶环的单取代苯磺酰脲化合物 ,其结构经 1 H NMR及元素分析确证 .用油菜根长法测定 IC50 ,并进行盆栽除草活性测试 ,结果表明 ,嘧啶环 4位取代基的变化对分子除草活性影响较大 ,活性大致按烷氧基。In order to develop new herbicidal active structures and research the structure-activity relationship, on the basis of the known monosubstituted phenylsulfonylureas with a high activity we designed and synthesized 14 novel sulfonylurea compounds with a single substituting group, such as alkoxy, alkylthio and alkylamino in the pyrimidine ring. The structures of all compounds were confirmed by 1H NMR spectra data and elemental analysis. Herbicidal activitiy including IC 50 was determined by rape root length experiment and pot experiment. The results show that the variation of 4- substituting group of the pyrimidine ring affects the activity of the compounds respectively. Herbicidal activity decreases in the sequence of alkoxy, alkylthio and alkylamino substituent.

关 键 词：磺酰脲 除草剂 合成 嘧啶 

分 类 号：O626.41[理学—有机化学]