大豆黄酮对衰老小鼠脑组织抗氧化能力的影响  

The Effects of Daidzein on the Antioxidation Level in Brain of Aged Mice

作　　者：刘文[1] 陆军[2] 陈龙 单群[2] 才金玲[2] 沈露露[2] 程超[2] 郑元林[2] 

机构地区：[1]徐州师范大学江苏省药用植物生物技术重点实验室,江苏徐州221116 [2]徐州师范大学生命科学学院,江苏徐州221116 [3]江苏省资源生物技术重点实验室,江苏南京210008

出　　处：《徐州师范大学学报（自然科学版）》2004年第4期41-44,共4页Journal of Xuzhou Normal University(Natural Science Edition)

基　　金：江苏省重点实验室开放基金资助项目(KJS02024);江苏省教育厅自然科学基金资助项目(98KJB180003;03KJD180219)

摘　　要：用大豆黄酮(daidzein)灌喂脑老化模型小鼠.5周后分别测定各组小鼠脑组织的超氧化物歧化酶(SOD)活性、乳酸脱氢酶(LDH)活性、总抗氧化能力(T AOC)和丙二醛(MDA)含量.结果显示:大豆黄酮能够使脑老化模型小鼠的SOD的活力和T AOC显著增加,LDH的活力和MDA的含量极显著下降,其中T AOC和MDA超过了生理盐水对照组,暗示大豆黄酮除了通过提高SOD的活性来增加机体抗氧化能力外,还存在通过其他的途径来提高机体的抗氧化能力,并且大豆黄酮在抗氧化水平上还有一定的剂量效应.Several groups of brain-aged model mice were fed with daidzein for 5 weeks and then their activities of SOD and LDH,the content of MDA,and T-AOC were determined.The results show that daidzein can remarkably increase their acticity of SOD and T-AOC,and decrease the activity of LDH and the content of MDA,where the T-AOC and MDA are found higher than the conparison group with physiological saline.This suggests that for daidzein there are some other ways to raise the antioxidation of an organism body besides increasing the activity of SOD.Moreover,there is a dose-effect connected with the antioxidation level.

关 键 词：脑组织 脑老化 模型小鼠 抗氧化能力 衰老小鼠 MDA 含量 大豆黄酮 活力 活性 

分 类 号：R285.5[医药卫生—中药学] S816[医药卫生—中医学]