傅里叶变换红外光谱法研究肺组织切片  

FTIR Study on Normal and Cancerous Lung Tissues

作　　者：程存归[1] 施红旗[2] 朱晓军[2] 郑荣泉[1] 朱寿田[2] 

机构地区：[1]浙江师范大学化学与生命科学学院,浙江金华321004 [2]浙江省金华市中心医院,浙江金华321000

出　　处：《光谱学与光谱分析》2004年第11期1342-1344,共3页Spectroscopy and Spectral Analysis

摘　　要：采用傅里叶变换红外光谱(FTIR)仪并借助OMNI采样器直接、快速地测定了正常肺组织及肺癌组织的红外光谱,通过研究表明,正常肺组织与肺癌组织样品的红外光谱在峰位、峰强及峰形等方面均存在明显而有规律的红外光谱差异,这反映了组织中的蛋白质、核酸和脂类等生物分子在不同性质的组织中含量上的差异。研究表明,FTIR可从分子水平上揭示正常肺组织和肺癌组织的特性,能对正常肺组织和肺癌组织的良、恶性的鉴别提供丰富而可靠的结构信息。Tissues of cancerous and normal lungs were analysed directly and fast by Fourier transform infrared spectroscopy with OMNI-sampler. The result indicated that some remarkable spectral differences were among normal and cancerous lung tissues in frequency, intensity and shape of the. absorption peaks. These facts indicated significant differences of content, structure and conformation of proteins, nucleic acids and lipids in different types of lung tissues. The present results suggested that Fourier transform infrared spectrometry(FTIR) could show the properties of normal and cancerous lung tissues at the molecular level. It was able to provide rich and reliable information for investigation of normal and cancerous lung tissues and could be used as a convenient and reliable diagnostic tool for some tumors.

关 键 词：肺组织 正常 肺癌组织 傅里叶变换红外光谱法 恶性 鉴别 含量 FTIR 峰形 结构信息 

分 类 号：O657[理学—分析化学] R734.2[理学—化学]