Meynert基底核的老龄改变及相关因素  

Age-related Changes of Basal Nucleus of Meynert and Its Related Factors

作　　者：赵海花[1] 赖红[1] 吕永利[1] 

机构地区：[1]中国医科大学解剖学教研室,辽宁沈阳110001

出　　处：《解剖科学进展》2004年第4期371-374,共4页Progress of Anatomical Sciences

摘　　要：年龄的增长将伴随认知功能不同程度的衰退或障碍。近年来对有认知功能障碍疾病的研究表明 ,在老龄认知功能障碍时 ,基底前脑Meynert基底核 (简称NBM )内的胆碱能神经元显著丢失 /萎缩 ,不仅其本身的代谢活性减低而且还累及到NBM投射区 (即皮质 )的形态及功能的改变。NBM内神经元退行性改变的机制虽尚未明确 ,但动物实验表明 ,这很可能是神经元营养供应不足或缺乏的结果。本文将对NBM神经元退行变及其神经营养机制作进一步的讨论。Declines in cognitive function accompany normal aging i n humans. More recent studies have demonstrated that normal aging and cognitive dy sfunction is associated with significant cell loss/atrophy and reduction in cell metabolic functions in nucleus basalis of Meynert (NBM). The changes of NBM als o affected the morphology and functions of neurons in cortex. Although the mecha nism of these age-related changes remained poorly defined, the experimental stud ies from animals showed that neurotrophic dysfunction would be responsible for i t. In this review, we discussed these age-related changes and its neurotrophic mechanism in details.

关 键 词：退行性改变 胆碱能神经元 认知功能障碍 老龄 相关因素 基底前脑 神经营养 机制 制作 萎缩 

分 类 号：Q421[生物学—神经生物学] R749[生物学—生理学]