尿毒症患者活动性巨细胞病毒感染的发生状况及其对肾移植的影响  

Active cytomegalovirus infection before renal transplantation and it’s affection on the uremia patients

作　　者：王平贤[1] 龚桂枝[1] 张艮甫[1] 黄赤兵[1] 范明齐[1] 冯嘉瑜[1] 肖亚[1] 方针强[1] 

机构地区：[1]第三军医大学附属新桥医院泌尿外科,重庆市400037

出　　处：《实用医学杂志》2004年第12期1357-1360,共4页The Journal of Practical Medicine

摘　　要：目的 :了解肾移植患者术前活动性巨细胞病毒 (CMV)感染的发生状况及其对术后的影响。方法 :自2 0 0 2年 6月至 2 0 0 3年 12月 ,检测 196例肾移植患者术前外周血CMV pp65抗原血症 ;肾移植后则每 2～ 4周检测 1次 ,共为期 6个月 ;分析术前CMV pp65抗原血症状况对术后患者CMV pp65抗原血症强度和CMV病发生率的影响 ;另于同期内检测 2 9例健康成人CMV pp65抗原血症作对照。结果 :2 9例健康成人CMV pp65抗原血症均为 (-) ;肾移植前有 11 2 % (2 2 / 196)的尿毒症患者CMV pp65抗原血症为 (+ ) ;这类患者肾移植后发生高活动性CMV感染 (即CMV pp65抗原血症指数 >10 0 )和CMV病的发生率均明显高于移植前CMV pp65抗原血症为 (-)的患者 ;肾移植后6个月内有 87 8% (172 / 196)的肾移植受者CMV pp65抗原血症为 (+ )。结论 :肾移植前活动性CMV感染为11 2 % ;肾移植后 6个月内活动性CMV感染高达 87 8% ;术前活动性CMV感染是导致肾移植后发生高活动性CMV感染和CMV病的重要原因。Objective To discover the matter of active cytomegalovirus (CMV) infection before renal transplantation and its affection on the uremia patients after transplantation. Methods The numbers of pp65 positive cells in peripheral blood in 29 normal persons who were used as control and 196 uremia patients before renal transplantation were determined between June 2002 and December 2003. The variations of number of pp65 positive cells in peripheral blood in patients after renal transplantation were investigated. Results In control group the number of pp65 positive cells in peripheral blood was 0/5×10 4 WBC. Before renal transplantation there was 11 2 percent of uremia patients whose pp65 positive cell counting was more than 0 cell/5×10 4 WBC. In this kind of patient the case number of serious active CMV infection (pp65 positive cell counting was more than 100 cells/5×10 4 WBC) and CMV disease after renal transplantation was more than others. The difference was significant. Conclusion The findings suggest that active CMV infection before renal transplantation is an important sake that causes serious active CMV infection and even CMV disease after renal transplantation.

关 键 词：肾移植 PP65 血症 患者 抗原 CMV感染 术前 活动性 结论 受者 

分 类 号：R692.5[医药卫生—泌尿科学]