Pimobendan对充血性心力衰竭模型大鼠左室重塑、死亡率及心功能的影响  

Effects of pimobendan on cardiac function, left ventricular remodeling and mortality in rat model of congestive heart failure induced by coronary artery ligation

作　　者：孟繁波[1] 吉川勉[2] 安斉俊久 前川裕一郎[2] 菅野康夫[2] 小川聡[2] 

机构地区：[1]吉林大学中日联谊医院心血管内科,长春130031 [2]日本庆应大学病院呼吸循环器科

出　　处：《临床心血管病杂志》2004年第12期730-733,共4页Journal of Clinical Cardiology

基　　金：卫生部课题资助 (卫生部国际合作司 2 0 0 4 0 73);第三十五批中国博士后科学基金资助 2 0 0 4 0 35 0 5 6 7;日中医学笹川奖学金资助 ;2 0 0 4年度吉林省杰出青年科学研究计划资助

摘　　要：目的 :研究 pimobendan(UD CG115 )对充血性心力衰竭 (CHF)模型大鼠左室重塑、死亡率以及心功能的影响。方法 :把心肌梗死后CHF模型大鼠分为 4组 ,Ⅰ组 :安慰剂组 ,Ⅱ组 :pimobendan 0 .1mg/kg组 ,Ⅲ组 :pimobendan 1mg/kg组 ,Ⅳ组 :假手术组 ,给予安慰剂。 结果 :4组大鼠在研究其间均无死亡。Pimobendan可以改善心功能 ,但不加重心室重塑 ,pimobendan 1mg/kg可以减少左室重塑。 结论 :①Pimobendan对CHF模型大鼠的死亡率无影响 (不增加死亡率 ) ;②Pimobendan对CHF大鼠的左室重塑无影响 ,但提高心功能 ;③对于广泛左室游离壁心肌梗死大鼠 ,1mg/kgpimobendan腹腔注射 。Objective: To investigate effects of pimobendan on left ventricular(LV) remodeling, mortality and cardiac function in CHF rats.Method: the rats model of congestive heart failure(CHF )was divided into 4 groups,Ⅰgroup: AMI+vehicles; Ⅱgroup: AMI+pimobendan 0.1 mg/kg; Ⅲgroup: AMI+pimobendan 0.1 mg/kg; Ⅳgroup: sham+vehicles. The pimobendan or vehicles was administrated i.p once a day for 2 weeks.Result:No one rat was death during the intervention period. Cardiac function could be improved and ventricular remodeling could not be affected by i.p pimobendan, once a day; pimobendan 1mg/kg can reduce ventricular remodeling. Conclusion:①there was no effect of pimobendan on mortality of CHF rats ( do not increase mortality). ②there was no effect of pimobendan on LV remodeling of CHF rats ( do not induce LV remodeling), but improve the cardiac performance. ③1 mg/kg pimobendan for i.p once a day can reduce the extent of LV remodeling in CHF rats with whole free wall infraction and cardiotonic effect increase with the increasing of pimobendan.

关 键 词：心力衰竭 充血性 磷酸二酯酶抑制剂 心室重塑 心功能 

分 类 号：R541.61[医药卫生—心血管疾病]