胎儿胸腺淋巴细胞功能性亚群的分化  

STUDY OF THE DIFFERENTIAL DEVELOPMENT OF FETAL THYMUS CELL

作　　者：刘宗印[1] 耿秀兰[2] 张孝卫[2] 任东俊[2] 黄丽华[2] 

机构地区：[1]济南市中心医院中心实验室 [2]济南市医学科学研究所

出　　处：《山东医科大学学报》1993年第2期157-158,161,共2页Acta Academiae Medicinae Shandong

摘　　要：为探讨T淋巴细胞在胸腺内的分化发育过程,用OKT系单克隆抗体,APAAP桥联酶标技术,对32例15周龄～32周龄的胎儿胸腺淋巴细胞进行了细胞表面分化抗原的检测和分析。结果表明,当胎龄15周时,胸腺内的淋巴细胞已分化发育成具有不同功能的细胞亚群,CD_8^+细胞随胎龄增长而增加,CD_4^+/CD_8^+比值随胎龄增长而降低,初步探讨了T淋巴细胞在胸腺内的分化发育过程。Immunocytochemistry APAAP technique with OKT mono- clonal antibodies was used to study differential antigenic detection and analysis of thymus lymphocytes in 32 fetuses.The results showed that different kinds of functional subsets appeared in fetal thymus lymphocytes.The number of CD^+_8 cells increased with growing of the fetus,and CD_4^+/CD_8^+ ratio decreased with growing of the fetus.

关 键 词：胸腺 淋巴细胞 胎儿 单克隆抗体 

分 类 号：R392.12[医药卫生—免疫学]