Short Synthesis of C-terminal Modified Peptides by a Series-connection Procedure  

作　　者：GuiJieTIAN ChuanLiangQIU ZheLIU DeXinWANG 

机构地区：[1]InstituteofMateriaMedicaChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100050

出　　处：《Chinese Chemical Letters》2005年第1期31-34,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China,grants No.30271530.

摘　　要：Three peptide alcohols and four peptidyl N-akyl-amides were prepared by a series-connection procedure consisting of n-1 sequencial assembly on solid support followed by ammonolysis with glycinol, benzylamine or n-butylamine, and successive extractionelution through C-18 layer. All products were obtained from this procedure without further purification, in an overall yield of 75-86%.Three peptide alcohols and four peptidyl N-akyl-amides were prepared by a series-connection procedure consisting of n-1 sequencial assembly on solid support followed by ammonolysis with glycinol, benzylamine or n-butylamine, and successive extractionelution through C-18 layer. All products were obtained from this procedure without further purification, in an overall yield of 75-86%.

关 键 词：AMMONOLYSIS C-18 filtration solid-phase synthesis. 

分 类 号：O623.736[理学—有机化学]