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机构地区:[1]北京大学第一医院,北京100034
出 处:《药物不良反应杂志》2004年第6期374-378,共5页Adverse Drug Reactions Journal
摘 要:目的:分析致肝损害的药物种类、临床表现及预后,探讨预防措施。方法:采取回顾性分析的方法,对本院2000年1月至2003年12月临床各科药物性肝损害的报表111份进行统计分析。结果:111例药物性肝损害中男58例,女53例,年龄最小8岁,最大82岁,平均(46.96±16.67)岁。涉及药物77种,抗菌药居首位占16.22%(18/111),激素及其有关药物占第二位,为15.32%(17/111),中枢神经系统用药、中药和抗肿瘤药居第三位,均占10.81%(12/111)。临床分型:肝细胞型损伤40例(36.04%),淤胆型肝损伤43例(38.74%),混合型肝损伤28例(25.22%)。结论:致肝损害的药物品种较多,虽然发现、治疗及时可痊愈或好转,但近半数病例起病隐匿。因此,定期检查肝功能,早期诊断,及时停药与治疗是预后良好的关键。Objective: To analyse the causative drugs, clinical manifestations and precautions of liver damage. Methods: 111 reports of drug-induced liver damage were presented by clinical departments in the hospital from January 2000 to December 2003 and retrospectively reviewed. Results: In 111 cases there were 58 males and 53 females,with a mean age of 46.96 years(range 8-82). 77drugs were involved,mainly antibacterials (18/111 cases,accounting for 16.22%),hormones and other related substances(17/111,15.32%), drugs acting on the CNS ,traditional Chinese medicines and antineoplastics (12/111,10.81%). Classification of drug-induced liver damage was made: hepatocellular damage(40 cases,36.04%),cholestatic damage (43cases, 38.74%)and mixed type damage(28cases, 25.22%). Conclusion: Routine liver function test, early diagnosis, immediate discontinuance of the causative drug and timely treatment are the key to management of drug-induced liver damage.
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