链霉素聚氰基丙烯酸正丁酯毫微粒的制备工艺研究  

Study on the preparation procedure of streptomycin sulfate nanoparticles

作　　者：桂卉[1] 范学工[1] 

机构地区：[1]中南大学湘雅医院,传染科,湖南长沙410008

出　　处：《解放军药学学报》2004年第6期408-411,共4页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：国家"8 63"子项目 ;No .2 0 0 1AA2 180 11;湖南省教育厅科研基金资助项目 ;No .湘教通 (2 0 0 1) 2 0 7

摘　　要：目的　对链霉素毫微粒的制备工艺进行研究 ,优选最佳制备工艺。方法　以可生物降解的氰基丙烯酸正丁酯为聚合材料 ,采用乳化聚合法制备SM PBCA NP ;以载药量、包封率、粒径分布为评价指标 ,通过单因素试验初选、均匀设计法精选 ,优化制备工艺。结果　按优化工艺条件 ,制得载药毫微粒 :平均粒径 76nm ,分布范围 30～ 12 0nm ,载药量 6 2 % ,包封率 87%。结论　经过优化筛选出的工艺 ,为链霉素聚氰基丙烯酸正丁酯毫微粒的最佳制备工艺。Aim To search for the best preparation procedure of streptomycin sulfate polybutylcyano acrylate-nanoparticles(SM-PBCA-NP).Methods SM-PBCA-NP was prepared by emulsing polymerization method with polybutylcyanoacrylate as carrier material; the procedure was optimized by single factor test and umiform design test with the ebedding ratio and drug loading as the test standard.Results Under this optimum condition,the mean diameter of the nanoparticles was 76 nm,the mean drug loading 68% and the mean ebedding ratio 89%.Conclusion The obtained condition was the best preparation procedure of MS-PBCA-NP.

关 键 词：毫微粒 链霉素 载药量 制备工艺 氰基 包封率 NP 丙烯酸正丁酯 平均粒径 可生物降解 

分 类 号：R94[医药卫生—药剂学] TQ225[医药卫生—药学]