谷氨酸锌和葡萄糖酸锌在家兔体内的药动学研究与比较  

Pharmacokinetics of zone lunatic and zone gluconate in rabbit

作　　者：李丽[1] 陈雄钢 秦群[2] 

机构地区：[1]肇庆市第一人民医院,药剂科,广东肇庆526021 [2]中南大学湘雅医院,药剂科临床药学室,湖南长沙410008 [3]不详

出　　处：《解放军药学学报》2004年第6期443-444,共2页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的　探讨谷氨酸锌和葡萄糖酸锌在家兔体内的药动学过程并作比较。方法　对正常家兔分别灌服及静注谷氨酸锌和葡萄糖酸锌 ,用原子吸收分光光度法测定血清中锌的浓度。结果　口服谷氨酸锌和葡萄糖酸锌在家兔体内的药动学过程均符合开放型一室模型 ,静注谷氨酸锌和葡萄糖酸锌在家兔体内的药动学过程均符合开放型二室模型。结论　口服谷氨酸锌较葡萄糖酸锌吸收快 ,达峰时间短 ,是一较好的补锌剂。Aim To study and compare the pharmacokinetics of zone lunatic and zone gluconate in normal rabbits.Methods After the normal rabbits were treated with zone lunatic and zone gluconate intravenous and oraly,zone concentration in serum were determined by AAS.Results Oraly zone lunatic and zone gluconate conformed to one-compartment open model in rabbit.Intravenous conformed to two-compartrment open model in rabbit.Conclusion Oral administration with Zine Lunatic and Zine Gluconate had a faster absoption,a faster arrived peak time and a longer MRT.

关 键 词：葡萄糖酸锌 体内 谷氨酸 药动学研究 家兔 静注 口服 灌服 浓度 原子吸收分光光度法 

分 类 号：R969.1[医药卫生—药理学] R781[医药卫生—药学]