二十二碳六烯酸抗心血管疾病作用的研究——Ⅲ.对家兔门静脉和绵羊血小板条张力的影响  

THE STUDIES ON EFFECT OF DOCOSAHEXAENOIC ACID UPON CARDIOVASCULAR DISEASE Ⅲ.THE INFLUENCE OF TENSION ON PORTAL VEIN IN RABBITS AND SHEEP PLATELET STRIPE

作　　者：张黎华[1] 王景梓[1] 徐红岩[1] 周序斌[1] 吴葆杰[1] 

机构地区：[1]山东医科大学药理学教研室

出　　处：《山东医科大学学报》1993年第3期181-184,共4页Acta Academiae Medicinae Shandong

基　　金：国家自然科学基金(39070929)

摘　　要：离体实验表明,二十二碳六烯酸(DHA)含量在1×10^(-5)～5×10^(-4)mol/L时,可使花生四烯酸(AA)引起收缩状态的兔门静脉松弛,且与剂量呈依赖关系;并可使门静脉管壁PGI_2含量升高,TXA_2不变,但作用明显弱于二十碳五烯酸(EPA)。Salganicoff血小板条实验表明,DHA明显抑制绵羊血小板条张力,使血小板TXA_2含量下降。EPA对血小板条作用与DHA相同。The influence of DHA on tension of rabbit protal veins andsheep platelet strip in vitro were investigated in comparison with EPA.Inthe concentration of 1×10^(-5)～5×10^(-4)mol/L,the portal veins contractedby AA were relaxed by DHA in dose dependently.The level of 6-keto-PGF_(1αin portal vein was enhanced but TXB_2 was not.The effect of DHAwere weaker than those of EPA.Tension of platelet strips with salganicoffmethod was investigated.DHA reduced the tension of platelet stripe andlevel of TXB_2 in platelets significantly.The effects of DHA on both thetension and the level of TXB_2 were the similar to those of EPA.

关 键 词：心脏血管疾病 DHA 血小板条 

分 类 号：R972.6[医药卫生—药品]