脂肪与创面愈合  

ADIPOSE TISSUES AND WOUND HEALING

作　　者：程飚[1] 付小兵[1] 盛志勇[1] 

机构地区：[1]解放军总医院304临床部全军创伤修复重点实验室

出　　处：《中国修复重建外科杂志》2005年第1期78-81,共4页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家重点基础研究发展规划资助项目 (G1 9990 542 0 4 ) ;国家杰出青年基金资助项目 (3952 50 2 4 ) ;国家自然科学基金重点项目(30 2 30 370 ) ;国家自然科学基金资助项目 (30 1 70 966) ;博士后基金资助项目 (2 0 0 1 .1 4 )~~

摘　　要：目的　探讨脂肪组织与创面愈合的关系。　方法　通过对近期文献的回顾 ,脂肪组织参与食物摄入、能量代谢等生理过程。通过内分泌、自分泌和旁分泌参与创面愈合的调节。　结果　脂肪组织主要分泌的几种因子 :瘦素、细胞因子、生长因子和脂质等参与创面愈合过程。　结论　脂肪组织在创面愈合过程中可能具有重要作用 ,进一步了解脂肪细胞与上皮形成间的关系有助于揭示创面愈合的机制。Objective To study the relationship between the adipose tissues and cutaneous morphogenesis on wound healing. Methods Adipose tissues' participation in regulation of food intake, energy expenditure, fuel metabolism, and a variety of other physiological processes was reviewed in the latest literature. The wound healing was regulated by endocrine, paracrine, and adipocyte derived molecules. Results Several factors secreted by adipose tissues (leptin, cytokines, growth factors, lipids, metallothioneins, ect) regulated wound healing. Conclusion Adipose tissues may play a vital role in the process of wound healing. Further understanding of the complex interaction between adipose cells and cutaneous morphogenesis is essential to explore the mechanism of wound healing.

关 键 词：创面愈合 脂肪组织 上皮 旁分泌 瘦素 生长因子 细胞因子 生理过程 能量代谢 自分泌 

分 类 号：R641[医药卫生—外科学]