养血调肝方对初老雌性大鼠神经内分泌免疫影响的实验研究  

Experimental Research of Yangxue Tiaogan Fang on Neuroendocrino-Immunological Effect of First Aging Female Rats

作　　者：袁静[1] 陈全珠[1] 侯正明[1] 刘先华[1] 章复清[1] 

机构地区：[1]安徽中医学院,安徽合肥230038

出　　处：《中国实验方剂学杂志》2005年第1期34-36,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：安徽省重点科研项目 (0 0 0 2 2 0 33);安徽省教委自然科学研究项目 (99 1 2 2 )。

摘　　要：目的 :探讨养血调肝方对初老雌性大鼠神经内分泌免疫方面的影响。方法 :选用自然衰老雌性大鼠 ,观察给予养血调肝方后用放射免疫分析法检测血浆促肾上腺素皮质激素 (ACTH) ,β 内啡肽 (β END) ,血清雌二醇 (E2 ) ,睾酮 (T) ,促卵泡激素(FSH) ,三碘甲状腺原氨酸 (T3)甲状腺素 (T4 )促甲状腺素 (TSH)白细胞介素 II(IL 2 ) ,肿瘤坏死因子 (TNF)的含量 ,并观察肾上腺、卵巢和胸腺脏器指数的变化。结果 :与初老对照组比 ,养血调肝方组的上述指标均有明显改善 ,且与六味地黄汤组比无显著差异。结论 :养血调肝方具有调节神经、内分泌、免疫的作用。AIM:To study the effect of Yangxue Tiaogan Fang(YXTGF) on neuroendocrino Immunological in first aging female rats.METHODS:In the first aging female rats with YXTGF and the same aged control,the following determinations,including adrenocorticotropine (ACTH),β endorphin (β END),estradiol (E 2),testosterone(T),follicle stimulating hormone (FSH),triiodothyronine(T 3),thyroxine(T 4),thyroid stimulating hormone (TSH),interleukin II(IL 2),tumour necrosis factor (TNF) in the blood,were carried out by radioimmunoassay and the weight indexes of adrenal,ovary and thymus were examined.RESULTS:The indexes of YXTGF group were improved respectively,and there was no significant difference between YXTGF group and Liuwei Dihuang Tang (Positive drug)group.CONCLUSION:It is suggested that YXTGF may regulate neuroendocrino Immunological function.

关 键 词：养血调肝方 初老期 雌性大鼠 神经内分泌免疫 

分 类 号：R285.5[医药卫生—中药学]