中药紫草抗生育作用的研究  

STUDY OF CHINESE DRUG ZICAO ON THE ANTIFERTILITY

作　　者：马保华 邴鲁军 王哲民[2] 杨立忠 

机构地区：[1]组织学与胚胎学教研室 [2]山东省中医药研究所

出　　处：《山东医科大学学报》1993年第1期34-36,共3页Acta Academiae Medicinae Shandong

摘　　要：为探讨中药紫草的避孕效果及作用机理,应用组织学和同位素放射免疫法对SD雌性大鼠进行了观察研究。结果表明,紫草有抑制大鼠卵泡发育与成熟的作用,用药后血清FSH和LH浓度下降,出现明显的抗生育效果。停药第45天,实验动物重现动情期,恢复正常生育力,这为临床中药避孕提供了实验证据。The effect of Zicao on the contraception was studied by the methods of histology and radioimmunoassay.The drug was poured into the stomach of SD rats for 21 days and 30 days.On the 21th and 30th day,the blood level of FSH and LH of treated group was reduced significently over controls.Under light microscope,no mature follicle was found,only a few primary follicles,and a lot of atresic follicles and primordial follicles were observed in the ovary of treated group.Mating tests showed that 66% of rats in the control groups fall pregnant on the 23th day after treatment,while the pregnant rate of treated group was zero.On the 45th day,the fertility of treated rats was recovered.During the whole experiment,no abnormal activity occured in treated animals.The result suggests that Zicao has no poison on the animal.This research privides the experimental evidence of Zicao applying to contraception in clinical.

关 键 词：紫草 避孕药 卵泡刺激素 大鼠 

分 类 号：R285.5[医药卫生—中药学]