褐藻小粘膜藻中的溴酚化合物  

Bromophenols from the brown alga Leathesia nana

作　　者：徐秀丽[1] 范晓[1] 宋福行[1] 石建功[2] 

机构地区：[1]中国科学院海洋研究所 [2]中国医学科学院中国协和医科大学药物研究所,北京100050

出　　处：《中国中药杂志》2005年第1期39-41,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学重点基金资助项目 (2 993 2 0 3 0 ) ;国家高技术发展计划(863计划 )专项 (2 0 0 1AA62 0 40 3 )

摘　　要：目的 :对褐藻小粘膜藻进行化学成分研究。方法 :利用正相硅胶柱色谱 ,SephadexLH 2 0柱色谱、反相HPLC及重结晶等分离手段和IR ,MS及NMR等结构鉴定方法。结果 :从小粘膜藻中分离鉴定了 6个溴酚类化合物 ,分别为 2 ,2′ ,3,3′ 四溴 4 ,4′,5 ,5′ 四羟基二苯甲烷 (1) ,2 ,2′,3 三溴 3′ ,4 ,4′ ,5 四羟基 6′ 乙氧甲基二苯甲烷 (2 ) ,2 ,3 二溴 4 ,5 二羟基苯甲醇 (3) ,2 ,3 二溴 4 ,5 二羟基苯甲基甲醚 (4) ,3 溴 4 羟基苯甲酸 (5 )及 2 溴 4 ,5 二羟基苯甲醛 (6 )。结论Objective: To investigate the chemical constituents of the brown alga Leathesia nana. Method: Compounds were isolated by normal phase silica gel, Sephadex LH-20 chromatography and reverse phase HPLC techniques. Their structures were elucidated with spectroscopic methods including IR, MS and NMR. Result: Six compounds were isolated from ethanolic extract of the brown alga L. nana and their structures were identified as 2,2′,3,3′-tetrabromo-4,4′,5,5′-tetrahydroxydiphenyl methane, 2,2′,3-tribromo-3′,4,4′,5-tetrahydroxy-6′-ethyloxymethyldiphenyl methane, 2,3-dibromo-4,5-dihydroxybenzyl alcohol, 2,3-dibromo-4,5-dihydroxybenzyl methyl ether, 3-bromo-4-hydroxybenzoic acid and 2-bromo-4,5-dihydroxybenzaldehyde. Conclusion: All these compounds were obtained from this species for the first time.

关 键 词：粘膜 褐藻 硅胶柱色谱 首次 LH 结构鉴定 MS 二羟基 甲基 二苯甲烷 

分 类 号：R284.1[医药卫生—中药学]