溴莫普林与甲氧苄啶体内抗菌作用比较  

Antibicterial effects of Brodimorprim in comparison with Trimethprim in vivo

作　　者：杨芳炬[1] 刘小康[1] 王浴生[1] 范爱兰[1] 张淑华[2] 欧珍蓉[2] 

机构地区：[1]华西医科大学药理教研室,成都610041 [2]四川抗菌素工业研究所药理室,成都610070

出　　处：《四川生理科学杂志》2000年第4期32-32,共1页Sichuan Journal of Physiological Sciences

摘　　要：试验用昆明种小鼠腹腔感染致死量的临床分离菌株,再给予溴莫普林(BDP)与甲氧苄啶(TMP)口服及皮下给药,分别求其ED_(50)。试验结果表明口服BDP及TMP对感染金葡菌95191的ED_(50)分别为31.6与62.0mg/kg,皮下注射分别为9.4与17.3mg/kg;对感染大肠杆菌小鼠BDP与TMP的ED_(50)口服分别为25.2与63.0mg/kg,与下注射为16.0与59.1mg/kg;对感染嗜血流感杆菌9501的ED_(50),口服分别为9.2与83.0mg/kg;皮下注射则分别为7.5与28.4mg/kg;对感染肺炎链球菌9511的口服ED_(50)分别为50.4与101.1mg/kg。结果表明BDP口服体内抗菌作用比TMP强,对嗜血流感杆菌要强9倍,对其它细菌要强2倍左右(p值均小于0.05～0.01)。BDP皮下给药的抗菌作用要强于口服。: ED50 of Brodimoprim (BDP) and Trimethoporim (TMP) p. o. and s. c. was assessed in mice infected with minimal lethal dose of clinical isolated bacterials. The results showed that EDso of S. aureus infection: BDP and TMP were 31.6 and 62.8mg/kg (p. o); 9.4 and 17.3mg/kg (s. c. ) respectively. ED50 of E. coli infection: 25.2 and 63.8mg/kg (p. o.), 16. 0 and 59. Img/kg (s. c.), ED50 of H. inflkenzac infection: 9. 20 and 83. Omg/kg (p. o.) and 7. 5 and 38.4mg/kg (s. c. ), ED50 of S. pneumoniae infection: 50.4 and 101. Img/kg (p.o. ). The results indicated that antibacterial activity in vivo of BDP was superior than that of TMP. The potency of BDP vs TMP administered orally was 9:1; in H. influenzae infection. On the other bacterial infections BDP was more than two times than that of TMP (P<0.05～0.01). The antibacterial effects of BDP s.c. was more active than p. o. in all infected mice.

关 键 词：口服 BDP ED50 感染 体内抗菌作用 甲氧苄啶 皮下 大肠杆菌 细菌 菌株 

分 类 号：R965[医药卫生—药理学]