利维爱(Livial)对去势雌兔动脉粥样硬化影响的病理学观察  

The Effect of Livial on Atherosclerosis in Ovariectomized Rabbits

作　　者：崔亚利[1] 赵德明[2] 于书敏[2] 

机构地区：[1]河北农业大学动物科技学院,河北保定071001 [2]中国农业大学动物医学院,北京100094

出　　处：《中国兽医学报》2005年第1期60-62,共3页Chinese Journal of Veterinary Science

摘　　要：以去势雌兔作为雌激素缺乏模型 ,研究了利维爱 (L ivial)对食饵性兔动脉粥样硬化的斑块及血管病理形态学变化的影响。将 30只 7～ 9月龄、体质量约 4 kg的新西兰大白兔随机分为 3组 :A组为去势后饲喂高胆固醇组 ,B组为假手术后饲喂高胆固醇组 ,C为去势后饲喂高胆固醇并补充利维爱组。饲养 12周后处死 ,测定胸主动脉 AS斑块的面积 ,在光镜和电镜下观察血管壁的病理组织学变化。结果 :假手术组和利维爱组硬化斑块面积均小于 A组 ,利维爱组斑块面积与 A、B组比较差异显著 ;假手术组和利维爱组血管的病理变化比 A组轻 ,利维爱组血管的形态学结构接近正常血管 ,病理变化最轻。由此认为 。An atherosclerosis animal model of ovariectomized rabbits was used to study the effect of livial on atherosclerosis plaque and vascular pathological changes.30 female New Zeland white rabbits were assigned to 3 groups.group A:ovariectomized.group B:sham operation.group C:ovariectomized and receiving livial.Each rabbit was given high cholesterol diet.12 weeks later,the aortic was taken for morphological analysis.Results:The plaque area in group C(0.10±0.02) was smaller than that in group A(0.75±0.24) and group B(0.56±0.27)(P<0.05).The pathological changes of vascular in group C decreased than that in group B and group C.Conclusions:Livial has a better effect on the prevention and treatment of the atherosclerosis.

关 键 词：利维爱 动脉粥样硬化 高胆固醇 血管 手术 病理学观察 斑块 去势 饲喂 病理变化 

分 类 号：R711[医药卫生—妇产科学] S858[医药卫生—临床医学]