糖皮质激素与长效β_2受体激动剂吸入及单纯激素吸入治疗小儿哮喘的对比研究  

The comparsion research of the clinical effect in the treatment of pediatric asthma with corticosteroid and long-acting β_2-agonist

作　　者：唐普润[1] 林明辉[1] 纪泽泉[1] 朱美华[1] 梁敏[1] 

机构地区：[1]广州医学院第二附属医院儿科,510260

出　　处：《中国实用儿科杂志》2005年第1期27-28,共2页Chinese Journal of Practical Pediatrics

摘　　要：目的　观察糖皮质激素与长效 β2 受体激动剂吸入及单纯糖皮质激素吸入治疗小儿哮喘的临床疗效差别。方法　广州医学院第二附属医院 2 0 0 2年 3月至 2 0 0 4年 5月儿科急诊及门诊诊断为哮喘的患儿 14 1例 ,按单双日进行随机分组 ,治疗组选用糖皮质激素与长效 β2 受体激动剂 (舒利迭 )吸入 ,对照组行单纯激素吸入 (辅舒酮 )治疗 ,对其临床疗效及肺功能指标进行比较并进行统计学分析。结果　接受舒利迭治疗并成功随访的有 6 3例 ,接受辅舒酮治疗并成功随访的有 6 2例 ,两者临床疗效指标比较差异经非参数检验具有统计学意义。同时PEFR之间比较 ,差异经方差分析同样具统计学意义。结论　对中到重度的哮喘患儿 ,糖皮质激素与长效 β2 受体激动剂吸入较单纯激素吸入治疗能较好地控制并改善哮喘的症状。Objective To compare the efficacy of corticosteroid and long acting β 2 agonist seretide (salmeterol/fluticasone propionate) and fluticasone solely to treat patients with moderate to severe asthma who were uncontrolled on existing corticosteroid therapy.Methods From Mar 2002 to Jun 2004,141 asthmatic patients were randomly divided into two groups.One group was treated with seretide twice daily and the other group was treated with fluticasone twice daily.The clinical effect index and PEFR and FEV1 were analyzed statistically.The results were analyzed by Mann Whitney test.Results There were 63 cases in seretide group and 62 cases in fluticasone group who were follow up examined and evaluated effectively the clinical effect.The clinical effect index and PEFR had statistically significant difference.Conclusion The combination therapy with corticosteroid and long acting β 2 agonist has better clinical effect as compared with the corticosteroid therapy solely.

关 键 词：哮喘 糖皮质激素 Β2受体激动剂 

分 类 号：R72[医药卫生—儿科]